A Research Study Investigating How Well the Medicine Zenagamtide Helps People With Excess Body Weight Lose Weight Compared to Semaglutide

Starting soon · Phase 3 · Has a placebo group

Conditions studied: Overweight, Obesity

In brief

The purpose of this study is to find out if zenagamtide is safe and effective for treating participants who have excess body weight compared to treatment with semaglutide.

Key facts

Study ID

NCT07668414

Run by

Novo Nordisk A/S

People needed

650

Starts

2026-09-22

Expected to finish

2028-10-10

Last updated by the study team

2026-06-25

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male or female (sex at birth).
• Age 18 years or above at the time of signing the informed consent.

You may not qualify if…

• Glycated haemoglobin (HbA1c) ≥ 6.5% (48 millimoles per mole [mmol/mol]) as measured by the central laboratory at screening.
• History of type 1 or type 2 diabetes mellitus as declared by the participant or reported in the medical records.
• Treatment with glucagon-like-peptide-1 (GLP-1) receptor agonists (RA), dual GLP-1/gastric inhibitory peptide (GIP) RAs (or any other GLP-1 based treatment) or amylin analogues within 1 year before screening.

Where it is running

• First Valley Medical Group — Lancaster, California, United States
• Desert Oasis Healthcare — Palm Springs, California, United States
• Western University of Health Sciences — Pomona, California, United States
• Artemis Insitute for Clin Res — San Diego, California, United States
• Med Home Development Grp — Washington D.C., District of Columbia, United States
• Encore Medical Research LLC — Hollywood, Florida, United States
• NextPhase Research — Hollywood, Florida, United States
• Jacksonville Ctr Clin Res — Jacksonville, Florida, United States
• PharmaDev Clinical Research Institute LLC — Miami, Florida, United States
• South Broward Research LLC — Miramar, Florida, United States
• Essence MD Research — Naples, Florida, United States
• Florida Inst For Clin Res LLC — Orlando, Florida, United States
• Oviedo Medical Research, LLC — Oviedo, Florida, United States
• Palm Beach Research Center — West Palm Beach, Florida, United States
• Encore Medical Research of Weston — Weston, Florida, United States
• Conquest Research — Atlanta, Georgia, United States
• Eastside Bariatric and Gen Surg — Snellville, Georgia, United States
• Chicago Research Center, Inc — Chicago, Illinois, United States
• Endeavor Health — Skokie, Illinois, United States
• Midwest Inst For Clin Res — Indianapolis, Indiana, United States
• Southern Clin Research — Zachary, Louisiana, United States
• Amicis Centers of Clinical Research — St Louis, Missouri, United States
• Ichor Research — Syracuse, New York, United States
• Southgate Medical Group, LLP — West Seneca, New York, United States
• University of North Carolina — Chapel Hill, North Carolina, United States

Full record on ClinicalTrials.gov

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