AMAZE 13: A Research Study Investigating How Well the Medicine Zenagamtide Helps People in Asia With Excess Body Weight Lose Weight
Starting soon · Phase 3 · Has a placebo group
Conditions studied: Obesity, Overweight
In brief
The purpose of this clinical study is to find out if zenagamtide is safe and effective for treating people who have excess body weight. There are 2 study treatments in this study taken as injections under the skin once a week. Participants will either get zenagamtide (the treatment being tested) or placebo (a treatment that has no active medicine in it). Which treatment participants get is decided by chance.
Key facts
- Study ID
- NCT07668401
- Run by
- Novo Nordisk A/S
- People needed
- 400
- Starts
- 2027-01-07
- Expected to finish
- 2029-01-11
- Last updated by the study team
- 2026-07-21
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Male or female (sex assigned at birth, inclusive of all gender identities).
- Age 18 years or above at the time of signing the informed consent
You may not qualify if…
- Glycated haemoglobin (HbA1c) ≥ 6.5% (48 mmol/mol) as measured by the central laboratory at screening.
- History of type 1 or type 2 diabetes mellitus.
- Treatment with glucagon-like-peptide-1 (GLP-1) receptor agonists (RA), dual GLP-1/gastric inhibitory peptide (GIP) RAs (or any other GLP-1 based treatment) or amylin analogues before screening.
Where it is running
- Osmania General Hospital — Hyderabad, Telangana, India
- All India Institute of Medical Science (AIIMS), Guwahati — Assam, India
- SMS Hospital — Jaipur, India
- GMERS Medical college and hospital — Vadodara, India
- OCROM Clinic_Internal medicine — Suita-shi, Osaka, Japan
- Kindai University Hospital_Department of Endocrinology, Metabolism and Diabetes — Sakai-shi, Osaka, Japan
- Medical Corporation Shinanokai Shinanozaka Clinic_Internal Medicine — Shinjuku-ku, Tokyo, Japan
- Tokyo-Eki Center-building Clinic_Internal Medicine — Tokyo, Japan
- Fukuwa Clinic_Internal Medicine — Tokyo, Japan
- ToCROM Clinic_Internal Medicine — Tokyo, Japan
- Hospital Canselor Tuanku Muhriz UKM — Cheras, Kuala Lumpur, Malaysia
- University Malaya Medical Centre — Lembah Pantai, Kuala Lumpur, Malaysia
- Hospital Miri — Miri, Sarawak, Malaysia
- Hospital Melaka — Malacca, Malaysia
- Hospital Putrajaya — Putrajaya, Malaysia
- Seoul National University Bundang Hospital_Endocrinology — Seoungnam-si, Gyeonggi-do, South Korea
- Ajou University Hospital_Family Medicine — Suwon, Gyeonggi-do, South Korea
- Pusan National University Yangsan Hospital_Family Medicine — Yangsan, Gyeongsangnam-do, South Korea
- Kyungpook National University Hospital_Family Medicine — Daegu, South Korea
- Konkuk University Medical Center_Endocrinology — Seoul, South Korea
- Ramathibodi Hospital — Bangkok, Thailand
- Siriraj Institute of Clinical Research — Bangkok, Thailand
- Thammasat Hospital_CRC — Pathum Thani, Thailand
- Songklanagarind Hospital — Songkhla, Thailand
- Nirmal Hospital Pvt. Ltd. — Surat, Gujarat, India
Full record on ClinicalTrials.gov
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