Vasopressor Agents in Pulmonary Hypertension Crisis
Starting soon · Not applicable
Conditions studied: Pulmonary Arterial Hypertension (PAH), Chronic Thromboembolic Pulmonary Hypertension (CTEPH), Hypertension, Pulmonary
In brief
Comparison of the efficacy and safety of three vasoactive agents-dopamine, norepinephrine, and epinephrine-in the treatment of patients with pulmonary hypertension crisis: prospective, randomised controlled trial monitored by haemodynamic monitoring
Key facts
- Study ID
- NCT07667829
- Run by
- China National Center for Cardiovascular Diseases
- People needed
- 75
- Starts
- 2026-06-01
- Expected to finish
- 2029-01-31
- Last updated by the study team
- 2026-06-25
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age > 18 years old;
- Signed informed consent form;
- Confirmed diagnosis of arterial pulmonary hypertension (PAH) and/or chronic thromboembolic pulmonary hypertension (CTEPH);
- Presenting with manifestations of pulmonary hypertensive crisis;
- Receiving both diagnosis and treatment in-hospital;
- No intravenous administration of the vasopressor drugs (including dopamine, norepinephrine, and epinephrine) under study at enrollment.
You may not qualify if…
- At SCAI stage D or stage E ;
- Patients who only receive a diagnosis but no treatment in the hospital;
- Uncontrolled hyperthyroidism;
- Complicated with angle-closure glaucoma;
- Hypersensitivity to the study drug;
- Ongoing use of halogenated hydrocarbon general anesthetics such as cyclopropane and halothane;
- Ongoing use of monoamine oxidase inhibitor (MAOI) antidepressants or anti-Parkinson drugs (phenelzine, tranylcypromine, isocarboxazid, moclobemide);
- Pregnancy;
- Already receiving the vasopressor drugs (dopamine, norepinephrine, epinephrine) under study at enrollment.
Where it is running
- Chinese Academy of Medical Sciences, Fuwai Hospital — Beijing, Beijing Municipality, China
- Guangdong Provincial People's Hospital — Guangzhou, Guangdong, China
- Zhongnan Hospital of Wuhan University — Wuhan, Wuhan, China
Full record on ClinicalTrials.gov
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