Respiratory Exacerbations in Children With Bronchopulmonary Dysplasia (BPD): A Case-Control Study

Recruiting now

Conditions studied: Severe Respiratory Exacerbation

In brief

This is an ambispective observational case-control study evaluating respiratory exacerbations in pediatric patients affected by bronchopulmonary dysplasia (BPD) compared with children without BPD. The study includes a retrospective cohort (January 2020 to September 2025) and a prospective cohort (from study approval to December 2030). Patients admitted to the Pediatric Emergency Department or Pediatric Unit for lower respiratory tract infections will be consecutively enrolled and managed according to standard clinical practice.

Key facts

Study ID

NCT07666438

Run by

IRCCS Azienda Ospedaliero-Universitaria di Bologna

People needed

800

Starts

2026-04-17

Expected to finish

2030-12-31

Last updated by the study team

2026-06-24

Who can join

Age: 0 and older, up to 7. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Corrected age ≥30 days and ≤7 years Acute lower respiratory tract infection
• At least one of:
• tachypnea for age SpO2 <94% increased work of breathing Gestational age <32 weeks Diagnosis of bronchopulmonary dysplasia according to NICHD 2018 definition

You may not qualify if…

• Grade ≥3 intraventricular hemorrhage Major congenital heart disease Neuromuscular disorders Chromosomal/genetic syndromes Primary pulmonary diseases Major skeletal dysplasia

Where it is running

• IRCCS Azienda Ospedaliero - Universitaria di Bologna, U.O. Pediatria — Bologna, Bologna, Italy (enrolling)

Full record on ClinicalTrials.gov

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