Intraarticular Injection of Botox and Hyaluronic Acid in Knee Osteoarthritis
Recruiting now · Not applicable
Conditions studied: Intraarticular Injection, Botox, Hyaluronic Acid, Knee Osteoarthritis
In brief
This study aims to compare the efficacy of intra-articular injection of Botulinum toxin and hyaluronic acid on pain in knee osteoarthritis.
Key facts
- Study ID
- NCT07666347
- Run by
- Tanta University
- People needed
- 50
- Starts
- 2026-06-24
- Expected to finish
- 2026-12-01
- Last updated by the study team
- 2026-06-25
Who can join
Age: 50 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age ≥ 50 years.
- Both genders.
- Chronic knee osteoarthritis (KOA) according to American College of Rheumatology criteria for the diagnosis of knee osteoarthritis.
- Third or fourth grade Kellgren and Lawrence system for classification of osteoarthritis based on radiological data, it is a common method of classifying the severity of osteoarthritis (OA) using five grades according to the following sites and projections.
You may not qualify if…
- History of intra-articular injection within the last 6 months,
- History of surgery on the knee joint or major trauma to the lower limb causing fracture.
- Body mass index (BMI) more than 40 kg/m2.
- Medical conditions affecting the joint or lower extremity function such as severe osteoporosis, rheumatoid arthritis, collagen vascular diseases, and gout.
- Diabetic patient.
- Any contraindication to intra-articular injections for instance immunodeficiency, coagulation defect or anticoagulation therapy taking or skin infection at the site of injection.
- Hypersensitivity to Botulinum toxin or hyaluronic acid.
Where it is running
- Tanta University — Tanta, El-Gharbia, Egypt (enrolling)
Full record on ClinicalTrials.gov
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