Morphology in Oral Rare Syndromes & Artificial Intelligence for Clinical Diagnosis
Starting soon · Not applicable
Conditions studied: Osteogenesis Imperfecta, Rare Bone Disorders, Hypophosphatemia, X-Linked, Mucopolysaccharidoses, Tooth Abnormalities, Palate; Deformity, Artificial Intelligence (AI), Machine Learning
In brief
MOSAIC aims to determine whether oro-dental morphological anomalies, particularly palatal morphology, associated with rare bone and cartilage diseases can be precisely characterized using 3D digital models analysed through geometric morphometrics. The study will also evaluate whether these morphological signatures can train an artificial intelligence (AI) algorithm to classify syndromes. A prospective monocentric case-control cohort will be constituted, including 3D intra-oral scans and associated clinical data. The final goal is to improve diagnostic accuracy and reduce diagnostic delay in rare bone disorders.
Key facts
- Study ID
- NCT07666269
- Run by
- University Hospital, Bordeaux
- People needed
- 240
- Starts
- 2026-09-01
- Expected to finish
- 2028-03-01
- Last updated by the study team
- 2026-06-24
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- For cases: Diagnosis of a rare bone and cartilage disorder confirmed by the Rare Disease Competence Center for Constitutional Bone Disorders (MOC) or Calcium and Phosphate Metabolism Disorders (CaP), genetically and/or clinically.
- Ability to undergo a 3D intra-oral scan;
- Ability of the participant to understand the information notice provided regarding the use of their medical data and 3D digital models for research purposes, and to express informed non-objection to participation in the research.
- For controls: healthy adults recruited in the Dental Medicine Department.
You may not qualify if…
- History of major orthodontic/orthognathic treatment;
- Craniofacial conditions unrelated to the studied diseases (e.g., cleft palate, non-target craniofacial syndromes);
- Impossibility to obtain a 3D optical impression;
- Refusal or inability of the participant to understand the information notice and/or to express informed non-objection to participation in the research.
Where it is running
- CHU de Bordeaux — Bordeaux, France
Full record on ClinicalTrials.gov
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