The 'Comprehensive Adherence Resource and Empowerment Support' (CARES) Study

Starting soon · Not applicable

Conditions studied: HIV

In brief

The primary aim of this study is to adapt the Comprehensive Adherence Resource and Empowerment Support (CARES) intervention to support adolescent girls and young women (AGYW) aged 16-24 in Zimbabwe and South Africa in effectively using various forms of pre-exposure prophylaxis (PrEP), specifically oral, ring, and injectable PrEP. Originally developed for a clinical trial setting, CARES has shown promising results in enhancing effective PrEP use through a structured mix of counseling, SMS/phone calls, and peer support for daily oral PrEP and the PrEP ring. However, its resource-intensive design requires adaptation for routine public health settings to ensure feasibility, fidelity, acceptability, and effectiveness. This adapted intervention will be tailored with input from AGYW, PrEP providers, and local stakeholders to support sustainable PrEP use and address HIV prevention needs among AGYW. Additionally, it will incorporate injectable PrEP and be modified to suit routine public health contexts. Once the components are finalized, the adapted CARES intervention will be evaluated for effectiveness, feasibility, fidelity, and acceptability.

Key facts

Study ID
NCT07666139
Run by
RTI International
People needed
2100
Starts
2026-07-01
Expected to finish
2028-10-31
Last updated by the study team
2026-06-26

Who can join

Age: 16 and older, up to 24. Sex: female. Healthy volunteers: accepted.

Where it is running

Full record on ClinicalTrials.gov

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