Prevention of Rebound Pain After Orthopaedic Surgery With Peripheral Nerve Block (REBOUND)_part B

Starting soon · Not applicable

Conditions studied: Post Operative Analgesia, Rebound Pain, Post Operative Pain, Acute

In brief

Rebound pain after peripheral nerve blocks reduces the benefits of regional anesthesia and increases opioid consumption. This rebound pain most likely results from suboptimal pain management, as patients receiving a peripheral nerve block are typically not given scheduled opioid doses. Oral Patient Controlled Analgesia (PCA) consists of an oral morphine prescription that allows patients to self-administer doses based on their pain score. This study will compare patients undergoing elective orthopaedic surgery under general anaesthesia or sedation with a peripheral nerve block, receiving oral morphine PCA either with or without additional scheduled oral morphine doses.

Key facts

Study ID: NCT07666009
Run by: Centre Hospitalier Universitaire Vaudois
People needed: 100
Starts: 2026-06-01
Expected to finish: 2027-09-01
Last updated by the study team: 2026-06-24

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Patients scheduled for elective orthopaedic surgery on the upper limb
Patients scheduled for elective orthopaedic surgery on the lower limb.
Score ASA I-III; Patients aged over 18 years; Signed informed consent.
Surgery under general anaesthesia or under sedation

You may not qualify if…

Refusal or inability to understand the informed consent
Allergy to any of the following medications: ropivacaine, paracetamol, ibuprofen, ketorolac, morphine,sufentanil, ondansetron, or dexamethasone
Patients with long term opioid treatment
Bleeding diathesis
Neurological disorders of the operated limb
Known renal insufficiency (eGFR <30 mL/min)
Known hepatic insufficiency (Child-Pugh class B or C);
Pregnant or breastfeeding women;
Alcohol dependence syndrome;
Patients under spinal anaesthesia;
Patients undergoing amputation procedures

Where it is running

CHUV, Centre Hospitalier Vaudois — Lausanne, Canton of Vaud, Switzerland

Full record on ClinicalTrials.gov

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