JUgular Gating for Upright Level Adjustment and Targeted Enhancement of Cerebral Perfusion
Starting soon
Conditions studied: Intracranial Pressure, Critical Care
In brief
Investigators aim to demonstrate that the evolution of intracranial pressure (ICP) is nonlinear and may be influenced by jugular vein collapse. This collapse is estimated to occur at the angle where the hydrostatic pressure of the blood column matches the central venous pressure, and it can be assessed using ultrasonography. This approach allows for the determination of an individualized tilt angle, optimizing cerebral perfusion pressure without compromising venous drainage.
Key facts
- Study ID
- NCT07665606
- Run by
- University Hospital, Bordeaux
- People needed
- 30
- Starts
- 2026-09-01
- Expected to finish
- 2027-03-31
- Last updated by the study team
- 2026-06-24
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients ≥ 18 years old
- Hospitalized in the neurocritical care unit or the trauma unit
- Scheduled for nursing care requiring a supine position.
- Arterial catheter allowing continuous measurement of mean arterial pressure.
- Central venous catheter for continuous measurement of central venous pressure.
- External ventricular drain or intracranial pressure sensor for intracranial pressure monitoring.
- Bed with controlled inclination capability.
- Clinically stable condition allowing transient positional changes (as judged by the clinician).
- Not included, or planned to be included in another trial.
You may not qualify if…
- Contraindication to trunk mobilization.
- Being a minor or placed under supervision.
- Hemodynamic or respiratory instability.
- Uncontrolled intracranial hypertension, refractory arterial hypertension, or severe dysautonomia.
- Pregnancy or breastfeeding.
- Refusal to participate in the study.
Where it is running
- Bordeaux university hospital — Bordeaux, France
Full record on ClinicalTrials.gov
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