Acupuncture Mechanism in Relief of Gag Reflex

Recruiting now · Not applicable

Conditions studied: Gag (Pharyngeal) Reflex

In brief

The gag reflex relief effect of acupuncture of CV24 acupoint will be compared to acupuncture of PC6 and K3 acupoints in healthy volunteers in crossover mode. Second step will be the investigation whether local anesthesia using EMLA creme will block the gag relief effect of CV24 acupuncture in healthy volunteers.

Key facts

Study ID

NCT07664826

Run by

University Medicine Greifswald

People needed

30

Starts

2026-01-21

Expected to finish

2026-08-01

Last updated by the study team

2026-06-24

Who can join

Age: 20 and older, up to 40. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy volunteers aged between 20-40 years old with an American Society of Anesthesiologists physical status of I to II naïve to acupuncture
• Participants without previous opioid and psychotropic medication
• Without use of recreational drugs 3 days prior to study sessions
• Without systemic disease or local skin lesions at the sites of acupuncture
• Without drug allergy to local anesthetics, especially EMLA preparation
• Participants who have given written informed consent

You may not qualify if…

• Local skin infection at the sites of acupuncture
• Aged < 20 or > 35 years
• History of drug allergy to local anesthetics
• Participants who are unable to understand the consent form or to use numeric rating scale NRS-11
• Discontinuation Criteria
• Any adverse effects during study session
• In case of local or systemic infection
• In case if subject will withdraw from participation in this study at any time, for any reason, specified or non-specified, and without penalty or loss of benefits

Where it is running

• University Medicine of Greifswald — Greifswald, Germany (enrolling)

Full record on ClinicalTrials.gov

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