Novel Method for Removal of Orally Deposited Inhaled Fluticasone Propionate

Starting soon · Phase 4

Conditions studied: Asthma

In brief

This study is to find out if an Extra Virgin Olive-Oil-based Water (EVOOW) mix, removes more Fluticasone Propionate (FP) from the mouth than Water alone. 2 strengths of the EVOOW mix will be tested, one with equal parts EVOO and Water (50/50) and one with 3 parts EVOO and 1 part Water (75/25). Removing more FP deposits may help decrease the risk for obstructive sleep apnea (OSA), candidiasis (thrush), and speech and swallow dysfunction. Participants will be on study for up to 3 weeks.

Key facts

Study ID

NCT07664527

Run by

University of Wisconsin, Madison

People needed

20

Starts

2026-08-01

Expected to finish

2027-04-01

Last updated by the study team

2026-07-29

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy adults and adults with asthma, age 18 years and older
• Willing to hold orally and nasally inhaled corticosteroids (ICS) for 24h and 12h, respectively, before study visits with mouthwash sample collections (Visit 2 and Visit 3)
• No systemic or topical ocular corticosteroid use for the prior 4 weeks.

You may not qualify if…

• Known hypersensitivity to fluticasone propionate
• Allergy to olives or olive oil
• Known allergy to oxymetazoline
• Current smoking or vaping
• Currently pregnant or trying to become pregnant.

Where it is running

• University of Wisconsin — Madison, Wisconsin, United States

Full record on ClinicalTrials.gov

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