Cognitive and Electrophysiological Assessment of Non-Invasive Temporally-Interfering Electric Fields Stimulation (TIEFS)
Recruiting now · Not applicable · Has a placebo group
Conditions studied: Epilepsy
In brief
The goal of this clinical trial is to learn how a non-invasive brain stimulation method called Temporally Interfering Electric Fields Stimulation (TIEFS) affects brain activity and thinking in adults. TIEFS uses electrical currents applied to the scalp to influence brain activity without surgery. The main questions this study aims to answer are: * How does TIEFS change brain signals measured with brain recordings? * Does TIEFS affect thinking abilities such as memory, language, movement, or perception? * Is TIEFS safe and well tolerated when used in people? This study includes two groups of participants. One group includes adults with epilepsy who are already undergoing specialized brain monitoring as part of their medical care. The other group includes healthy adults with no history of seizures. Participants will: * Receive brief sessions of TIEFS using electrodes placed on the scalp * Complete computer-based tasks that test memory, attention, language, or movement. Answer questions about how the stimulation feels * Have brain activity recorded during the study Each study visit lasts up to three hours and may occur in one or two sessions. Information from this study may help researchers better understand the human brain and support the development of future non-invasive brain stimulation treatments.
Key facts
- Study ID
- NCT07663578
- Run by
- University of California, Davis
- People needed
- 15
- Starts
- 2025-04-16
- Expected to finish
- 2027-04-15
- Last updated by the study team
- 2026-06-23
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Adult patients (age 18-65 years of age) undergoing an intracerebral electrophysiology study for epilepsy pre-surgical evaluation are eligible for inclusion.
- For healthy control subjects are also eligible for inclusion (Scalp EEG measurements).
- Participants must be able to sufficiently speak and understand English or Spanish for consent and be able to understand and complete cognitive tasks.
- All subjects must have the ability to give valid informed consent.
You may not qualify if…
- No pregnant women will be recruited.
- People with implanted electrical devices such as Deep Brain Stimulation devices or Pacemakers.
- No prisoners will be recruited.
Where it is running
- University of California Davis Medical Center — Sacramento, California, United States (enrolling)
Full record on ClinicalTrials.gov
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