Electroacupuncture for Preventing Chemotherapy-Induced Peripheral Neuropathy in Patients With Early-stage Cancer

Starting soon · Not applicable · Has a placebo group

Conditions studied: Electroacupuncture, Chemotherapy, Peripheral Neuropathy, Early Stage Cancer

In brief

This randomized controlled clinical trial aims to clarify the clinical efficacy and safety of electroacupuncture combined with thumbtack needle for the prevention of chemotherapy-induced peripheral neuropathy(CIPN), and to provide high-level evidence-based medicine for the prevention of CIPN in patients with early stage cancer. At the same time, the effects of electroacupuncture on the median nerve, tibial nerve, sural nerve sensory conduction velocity and sensory nerve action potential, as well as on the median nerve and tibial nerve motor conduction velocity will be analyzed.

Key facts

Study ID: NCT07663396
Run by: Affiliated Hospital of Qinghai University
People needed: 278
Starts: 2026-05-25
Expected to finish: 2029-07-31
Last updated by the study team: 2026-06-23

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Age ≥ 18 years.
Pathological and imaging examinations confirmed the diagnosis of early-stage cancer(I-III stage), including: breast cancer, gastric cancer, intestinal cancer, non-small cell lung cancer or ovarian cancer.
Eastern Cooperative Oncology Group Performance Status of 0 or 1.
Scheduled to receive chemotherapy containing a taxane, utidelone, or oxaliplatin, with no significant pre-existing neurological symptoms prior to chemotherapy. Specific regimens include: Colorectal cancer: Oxaliplatin-containing regimen. Gastric cancer: Oxaliplatin-containing or taxane-containing regimen. Breast cancer: Taxane-containing or utidelone-containing regimen. Non small cell lung cancer or Ovarian cancer: Taxane-containing regimen.
No history of acupuncture treatment within one month prior to study initiation.
Adequate major organ function, meeting the following laboratory criteria: Hematology: Absolute neutrophil count ≥ 1.5 × 10\^9/L; Platelet count ≥ 100 × 10\^9/L; White blood cell count 3.5 - 9.5 × 10\^9/L; Hemoglobin ≥ 100 g/L. Hepatic Function: Total bilirubin ≤ 1.5 × upper limit of normal; Aspartate aminotransferase and alanine aminotransferase ≤ 3 × ULN; Serum bilirubin concentration < 1.5 mg/dL; Serum albumin > 2.5 g/dL. Renal Function: Serum creatinine ≤ 1.5 × ULN, OR calculated creatinine clearance ≥ 50 mL/min (using the Cockcroft-Gault formula). Coagulation: International normalized ratio ≤ 1.5, AND activated partial thromboplastin time ≤ 1.5 × ULN.
Willing to receive acupuncture intervention and undergo subsequent follow-up assessments.
Voluntarily agree to participate in the study and sign an informed consent form.

You may not qualify if…

Patients with advanced cancer.
Pre-existing peripheral neuropathy prior to the initiation of chemotherapy.
Severe impairment of major organ function, rendering the patient unable to tolerate standard-dose chemotherapy.
Presence of active skin infection or other conditions unsuitable for acupuncture treatment.
Coexisting underlying diseases associated with peripheral neuropathy, such as diabetes mellitus, Guillain-Barré syndrome, or chronic inflammatory demyelinating polyradiculoneuropathy.
Current use of medications for neuropathic pain (e.g., gabapentin, pregabalin).
Pregnant or lactating patients.
Presence of dermatological conditions, as assessed by the clinician, that may interfere with the study procedures or outcomes.
Patients with active brain metastases.
Patients with a history of implanted cardiac pacemakers or defibrillators, or a history of epilepsy.

Where it is running

Qinghai University Affiliated Hospital — Xining, Qinghai, China

Full record on ClinicalTrials.gov

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