Ultrasonic Activated Irrigation and Intracanal Cryotherapy for Reducing Pain After Root Canal Treatment

Starting soon · Not applicable

Conditions studied: Symptomatic Irreversible Pulpitis and Post Operative Pain

In brief

This randomized controlled trial aims to evaluate the effect of ultrasonic activated irrigation with and without intracanal cryotherapy on postoperative pain following single-visit root canal treatment in teeth with symptomatic irreversible pulpitis. Participants requiring root canal treatment will be randomly allocated into two groups. One group will receive ultrasonic activated irrigation alone, while the other group will receive ultrasonic activated irrigation followed by intracanal cryotherapy. Postoperative pain will be assessed at predetermined time intervals using a standardized pain assessment scale. The findings of this study may help identify effective strategies for reducing postoperative pain after root canal treatment and improving patient comfort and treatment outcomes.

Key facts

Study ID

NCT07663227

Run by

Dr Arsalan Ali Khan

People needed

60

Starts

2026-08-01

Expected to finish

2027-03-01

Last updated by the study team

2026-06-23

Who can join

Age: 20 and older, up to 50. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 1. Patients who are medically fit (ASA Physical Status I) and aged between 20 and 50 years will be recruited for the study.
• Mandibular first or second molars exhibiting signs of symptomatic irreversible pulpitis, identified through an extended sensitivity to cold testing and/or a positive electric pulp test.
• Vital pulp with no signs of apical pathology (normal periapical radiograph, no swelling, sinus tract, or mobility).
• Mature roots with closed apices and no prior root canal treatment. 5. Willing to undergo single-visit treatment and comply with follow-up.

You may not qualify if…

• 1.Use of analgesics or NSAIDs within 12 hours prior to treatment. 2.Pregnant or lactating women. 3.Presence of systemic illness or allergy to any materials used in the study. 4.Teeth with:
• Non-vital pulp, periapical radiolucency, or sinus tract.
• Mobility > Grade I or periodontal pockets > 5 mm.
• Resorption, calcification, or non-restorable crown structure. 5.Third molars (wisdom teeth). 6.Endodontically treated tooth. 7.Inability or unwillingness to follow study instructions or complete follow-up.

Full record on ClinicalTrials.gov

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