Tackling Resistance And HealthCare Economics Through CPE Screening

Starting soon · Not applicable

Conditions studied: Carbapenem-Resistant Enterobacteriaceae, Colonisation

In brief

The goal of this clinical study is to learn if it is possible to reduce the spread of resistant bacteria called CPEs (Carbapenemase producing Enterobacterales) between patients admitted to hospital. CPEs can be carried in the gut of people without making them ill. Normally when patients come into hospital, they may undergo a swab test on their bottom to see if CPEs can be grown. This test can take up to 24 hours to produce a result. The investigators want to use a faster test which takes 2 hours to produce a result, and whether this can make a difference to CPE spread between person to person. The main questions it aims to answer are: 1. Why do people carry, transmit or get infected with CPE? 2. If a faster test was used to look for CPE, would this be better at reducing patient spread in hospital? 3. Is a faster test also more cost effective? Participants will: 1. Be tested by both the usual and faster test when they come into hospital by a swab on their bottom 2. Where they test positive for CPE they will be asked to answer some questions about their health

Key facts

Study ID

NCT07663110

Run by

Imperial College London

People needed

16000

Starts

2026-08-01

Expected to finish

2028-03-31

Last updated by the study team

2026-06-23

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• All adult (18 years or older) medical patients admitted to the acute medical unit during the implementation period who undergo routine rectal CPE testing as per local Trust policy and test positive for CPE colonisation through either the rapid test or culture-based methods.

You may not qualify if…

• Patient refusal for rectal screening or
• Clinical contraindication to rectal swab collection

Where it is running

• Charing Cross Hospital — London, United Kingdom
• St Thomas' hospital — London, United Kingdom

Full record on ClinicalTrials.gov

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