Comparison of Norepinehrine Versus Phenylepherine Infusion for Prevention of Post-spinal Hypotension
Recruiting now · Phase 4
Conditions studied: Patients Undergoing Orthopedic Hip Surgery Under Spinal Anesthesia, Orthopedic Hip Sugery in Eldely Patients
In brief
This prospective randomized double-blinded clinical trial aims to compare the efficacy and hemodynamic effects of prophylactic norepinephrine infusion versus phenylephrine infusion for prevention of spinal anesthesia-induced hypotension in elderly patients undergoing elective orthopedic hip surgery under subarachnoid block. Sixty-two patients aged 60 years or older will be randomly assigned into two equal groups to receive either norepinephrine infusion (8 µg/min) or phenylephrine infusion (100 µg/min) immediately after spinal anesthesia. The primary outcome is the mean heart rate during vasopressor infusion, while secondary outcomes include incidence of hypotension, severe hypotension, bradycardia, reactive hypertension, intraoperative fluid requirements, blood loss, transfusion requirements, and postoperative nausea and vomiting. Hemodynamic parameters will be monitored throughout surgery to evaluate the safety and effectiveness of both vasopressor strategies.
Key facts
- Study ID
- NCT07662408
- Run by
- Sohag University
- People needed
- 62
- Starts
- 2026-05-22
- Expected to finish
- 2027-03-14
- Last updated by the study team
- 2026-06-23
Who can join
Age: 60 and older, up to 100. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Age 60 years or older.
- ASA physical status I-III.
- Scheduled for elective hip surgery under subarachnoid block.
- Willing to provide written informed consent.
You may not qualify if…
- Patient refusal.
- Contraindications to subarachnoid block.
- Severe cardiac disease.
- Uncontrolled hypertension.
- Allergy to study drugs.
- Emergency surgery.
- Monoamine oxidase inhibitor use.
- Cognitive impairment preventing informed consent.
Where it is running
- Sohag university hospital — Sohag, Egypt (enrolling)
Full record on ClinicalTrials.gov
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