Cousin vs. Sibling Donors in Haplo-HSCT

Starting soon

Conditions studied: Hematopoietic Malignancies, Haploidentical Hematopoietic Stem Cell Transplantation, Donor

In brief

This observational study aims to emulate a hypothetical pragmatic, multicenter, non-blinded clinical trial enrolling adult patients undergoing haploidentical hematopoietic stem cell transplantation (haplo-HSCT) with grafts derived from either cousin or sibiling donors. The main research question is whether cousin donor-derived haplo-HSCT is associated with inferior clinical outcomes relative to sibling donor-derived haplo-HSCT. Study participants consist of adult patients diagnosed with hematological malignancies who underwent cousin or sibiling haplo-HSCT between 2017 and 2024, and all eligible recipients will receive regular follow-up assessments.

Key facts

Study ID

NCT07662382

Run by

The First Affiliated Hospital of Soochow University

People needed

1000

Starts

2026-08-01

Expected to finish

2027-10-31

Last updated by the study team

2026-06-23

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult patients diagnosed with hematological malignancies, including acute leukemia (AL), chronic myeloid leukemia (CML), myelodysplastic syndromes (MDS), myeloproliferative neoplasms (MPN), and non-Hodgkin lymphoma (NHL)
• Receipt of first haploidentical hematopoietic stem cell transplantation between 2017 and 2024
• Documented exact date of transplantation available in medical charts
• Verifiable donor kinship classified as either cousin or sibiling
• Complete longitudinal follow-up data accessible for outcome assessment

You may not qualify if…

• Prior receipt of any form of hematopoietic stem cell transplantation
• An age difference of more than 18 years between the donor and recipient
• Failure of successful infusion of donor-derived hematopoietic stem cells following conditioning regimen

Where it is running

• The First Affiliated Hospital of Soochow University — Suzhou, Jiangsu, China

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.