Taste Acceptance and Effectiveness of Hyaluronic Acid and Chlorhexidine Mouthwashes in Children With Gingivitis

Starting soon · Phase 1

Conditions studied: Plaque Induced Gingival Disease

In brief

This randomized controlled clinical trial aims to compare the taste acceptance and clinical effectiveness of hyaluronic mouthwash and chlorhexidine mouthwash in children with plaque-induced gingivitis. Clinical outcomes will be assessed using gingival and plaque indices, while taste acceptance will be evaluated using a validated hedonic scale. The findings may help identify a mouthwash that is both effective and acceptable to children, thereby improving adherence to oral hygiene practices.

Key facts

Study ID

NCT07662226

Run by

Cairo University

People needed

32

Starts

2026-08-01

Expected to finish

2027-05-01

Last updated by the study team

2026-06-23

Who can join

Age: 8 and older, up to 10. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Children aged from 8-12 years of both sexes.
• Children with a history of bleeding on brushing typical signs and symptoms of gingivitis.
• Healthy child (ASA I).
• Eruption of upper and lower permanent central and lateral incisors.
• Parent's agreement to sign the informed consent.
• Parent's ability for attending follow up visits.

You may not qualify if…

• Children -allergic to Chlorhexidine or Hyaluronic acid.
• Children with special health care needs or having a history of serious systemic disease that may affect the gingival health.
• Use of Systemic NSAIDs, steroids, or antibiotics within a month before the study.
• Children undergoing orthodontic treatment or having an intra-oral prosthesis.

Where it is running

• Faculty of dentistry, Cairo university — Cairo, Egypt, Egypt

Full record on ClinicalTrials.gov

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