Trans Auricular Vagal Nerve Stimulation in Patients With IBS-C
Starting soon · Not applicable · Has a placebo group
Conditions studied: Irritable Bowel Syndrome (IBS-C)
In brief
This study evaluates the efficacy and safety of transcutaneous auricular vagus nerve stimulation (ta-VNS) in adults with constipation-predominant irritable bowel syndrome (IBS-C). Participants will be randomized to receive either active or sham stimulation using a non-invasive auricular device over a 60-day period. The primary objectives are to assess changes in symptom severity and quality of life using validated instruments, including the IBS Symptom Severity Scale (IBS-SSS) and the IBS Quality of Life questionnaire (IBS-QOL). Secondary assessments include safety and participant compliance. This study aims to determine whether ta-VNS is an effective non-invasive therapeutic modality for improving symptoms and quality of life in patients with IBS-C.
Key facts
- Study ID
- NCT07662083
- Run by
- West Virginia University
- People needed
- 80
- Starts
- 2026-07-01
- Expected to finish
- 2027-07-01
- Last updated by the study team
- 2026-06-23
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Referred to the WVU Department of Gastroenterology and Hepatology
- Diagnosis of IBS-C
You may not qualify if…
- Failure of second-line therapy with secretagogues (linaclotide, lubiprostone, plecanatide, or tenapanor)
- Failure of third-line therapy with tegaserod
- Known debilitating psychiatric illness
- Cognitive impairment
- Pregnancy
- Prisoners
- Active substance use disorder
- Concurrent opioid use
- History of major gastrointestinal surgery resulting in luminal alteration
- History of vagotomy
- Secondary causes of constipation (e.g., opioid use, uncontrolled hypothyroidism, celiac disease)
Where it is running
- West Virginia University- Gastroenterology and Hepatology — Morgantown, West Virginia, United States
Full record on ClinicalTrials.gov
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