Effect of Mobile-Based Home Cardiac Rehabilitation on Coronary Plaque
Recruiting now · Not applicable
Conditions studied: Coronary Artery Disease (CAD), Coronary Stenosis
In brief
This single-center, randomized controlled trial aims to evaluate the efficacy of a mobile internet-based, home-based cardiac rehabilitation program in patients with mild to moderate coronary artery stenosis. A total of 176 eligible participants will be randomized to receive either a personalized lifestyle intervention via a mobile platform or routine clinical care. The primary endpoint is the change in non-calcified coronary plaque volume, as measured by coronary computed tomography angiography (CTA) at 12 months. Participants will be followed for a total of 36 months to comprehensively assess the long-term impact of this digital lifestyle intervention on plaque progression and cardiovascular outcomes.
Key facts
- Study ID
- NCT07660419
- Run by
- China National Center for Cardiovascular Diseases
- People needed
- 176
- Starts
- 2024-12-31
- Expected to finish
- 2027-12-31
- Last updated by the study team
- 2026-06-22
Who can join
Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- 1.Diagnosis of mild-to-moderate coronary artery stenosis: presence of plaque in any coronary artery causing mild (<50%) or moderate (50%-69%) luminal stenosis.
- Age between 18 and 70 years. 3.Asymptomatic during exercise or recovery phases of cardiopulmonary assessment, including absence of angina, ST-segment depression, or complex arrhythmias at rest or during exercise.
- Normal troponin levels. 5.Provided signed informed consent.
You may not qualify if…
- 1. Severe coronary artery stenosis. 2.Presence of severe respiratory or cardiovascular diseases (e.g., acute myocardial infarction, acute tachyarrhythmia, pulmonary edema, severe aortic stenosis).
- Angina symptoms or signs during low-intensity exercise (<5 METs) or recovery. 4.Complex arrhythmias at rest or during exercise. 5.Hemodynamic abnormalities during exercise (e.g., failure of systolic blood pressure or heart rate to increase, or a decrease in blood pressure with increased exercise workload).
- Severe psychological disorders. 7.Left ventricular ejection fraction (LVEF) < 40%. 8.Elevated troponin levels. 9.Inability to undergo cardiopulmonary exercise testing due to neuromuscular or musculoskeletal disorders.
- Presence of other severe comorbidities. 11.Refusal to sign informed consent.
Where it is running
- Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College — Beijing, China (enrolling)
Full record on ClinicalTrials.gov
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