Vagus Nerve Stimulation for Myelopathy

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Degenerative Cervical Myelopathy

In brief

The objective of this study is to generate preliminary data to establish the feasibility and effectiveness of transauricular vagus nerve stimulation (taVNS) to improve post-operative outcomes of moderate to severe degenerative cervical myelopathy (DCM)

Key facts

Study ID

NCT07660250

Run by

Washington University School of Medicine

People needed

36

Starts

2026-04-14

Expected to finish

2028-05-01

Last updated by the study team

2026-06-22

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 18 years of age or older
• Moderate or severe degenerative cervical myelopathy according to the mJOA
• Decompression surgery planned

You may not qualify if…

• • Pregnancy
• Electrically active implants (e.g. pacemaker)
• Known diagnosis of amyotrophic lateral sclerosis, multiple sclerosis, rheumatoid arthritis, concomitant thoracic and/or lumbar stenosis, spine tumor, HIV-related myelopathy
• Ongoing cancer therapy
• Ongoing use of immunomodulating or suppressive medication
• Sustained bradycardia with a heartrate <50 beats per minute for > 5 minutes following admission.
• Prior cervical spine surgery

Where it is running

• Washington University — St Louis, Missouri, United States (enrolling)

Full record on ClinicalTrials.gov

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