Cardiovascular Assessment 5 Years After MIS-C
Recruiting now
Conditions studied: Multisystem Inflammatory Syndrome in Children (MIS-C), SARS-CoV-2 Infection
In brief
Multisystem inflammatory syndrome in children (MIS-C) is a severe complication associated with SARS-CoV-2 infection that frequently affects the cardiovascular system. Although acute cardiac abnormalities usually resolve, the long-term cardiovascular consequences of MIS-C remain uncertain. Previous follow-up of this cohort 2 years after MIS-C identified signs of subclinical cardiovascular abnormalities compared with healthy controls. This cross-sectional study aims to evaluate cardiovascular health in individuals 5 years after MIS-C. Participants with a history of MIS-C will be compared with age- and sex-matched healthy controls using cardiovascular imaging, vascular assessments, cardiopulmonary exercise testing, and biomarkers of endothelial injury.
Key facts
- Study ID
- NCT07659847
- Run by
- Medical University of Warsaw
- People needed
- 90
- Starts
- 2025-11-22
- Expected to finish
- 2027-03-31
- Last updated by the study team
- 2026-06-22
Who can join
Age: any. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- For the MIS-C group: History of MIS-C diagnosed according to World Health Organization (WHO) criteria
- For all participants: Written informed consent from a parent or legal guardian and, where applicable, assent/consent from participants aged 16 years or older /
You may not qualify if…
- MIS-C group:
- Known heart disease, including congenital heart disease.
- Significant chronic disease affecting growth, development, or daily functioning.
- Control group:
- Elimination diet.
- Competitive athletic training.
- Known heart disease, including congenital heart disease.
- Significant chronic disease affecting growth, development, or daily functioning.
Where it is running
- Medical University of Warsaw Children's Clinical Hospital — Warsaw, Masovian Voivodeship, Poland (enrolling)
Full record on ClinicalTrials.gov
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