Platelet-Rich Plasma for Partial Rotator Cuff Tears

Starting soon · Not applicable

Conditions studied: Partial Supraspinatus Tear, Rotator Cuff Tears (RCTs), Rotator Cuff Injury

In brief

The goal of this clinical trial is to learn whether platelet-rich plasma (PRP) injection, made from a participant's own blood, can help heal the tendon and improve shoulder symptoms in people with partial tears of the supraspinatus tendon. The main questions it aims to answer are: * Does PRP help the tendon heal? * Does PRP improve pain, shoulder movement, daily function, and shoulder magnetic resonance imaging (MRI) findings? Researchers will compare PRP plus standard of care (physical therapy) to standard of care alone to see if PRP leads to better healing and better clinical results. Researchers will also study if differences in specific biomolecules in PRP are associated with differences in treatment response. Participants will: * receive standard of care treatment, with or without PRP injection depending on the study group * have blood collected for PRP preparation * have their pain, shoulder movement, and shoulder function assessed * undergo shoulder MRI scans * be followed over time to measure healing and symptom improvement

Key facts

Study ID

NCT07659600

Run by

Universidade Nova de Lisboa

People needed

100

Starts

2026-06-01

Expected to finish

2029-12-01

Last updated by the study team

2026-06-22

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Eligible patients are at least 18 years old, and have clinical (VAS pain score ≥4, loss of >25% in ROM, positive in at least one clinical test such as Jobe, Neer, Drop arm, Hawins-Kennedy, Patte) and imaging findings compatible with partial supraspinatus tear, within 3 months of diagnosis.
• Patients may have undergone conservative treatments, including lifestyle modification, oral analgesics, or physical therapy, with the exception of shoulder injections.
• Must be willing to provide consent.

You may not qualify if…

• Patients less than 18 years old
• Patients with other or concomitant rotator cuff or shoulder muscle/tendon tear(s), complete tears, SLAP tears ≥ grade 2
• Patients with auto-immune based joint diseases, osteoarthritis (KL grade ≥ 2), adhesive capsulitis, infection, nerve-related conditions, immunocompromised conditions, malignancy, coagulopathy
• Patients on antiplatelet, anticoagulant, antitumor or immunosuppressive drugs
• Uncontrolled diabetes, other systemic disorders (hepatitis, rheumatoid arthritis)
• Pregnancy
• Shoulder instability
• Previous shoulder injection or surgery
• Unwillingness to provide informed consent

Full record on ClinicalTrials.gov

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