Intraoperative Assessment of Microcirculatory Function Using Vascular Occlusion Test During Liver Transplantation

Starting soon

Conditions studied: Liver Cirrhosis, Early Allograft Dysfunction

In brief

Early allograft dysfunction (EAD) remains one of the most important complications following orthotopic liver transplantation (OLT). Currently, there is no established intraoperative biomarker that reliably predicts graft dysfunction at an early stage. Near-infrared spectroscopy (NIRS) combined with the vascular occlusion test (VOT) is a non-invasive method for assessing tissue oxygenation and microcirculatory reserve. This prospective observational study aims to investigate whether VOT-derived parameters, including desaturation slope, recovery slope and post-ischemic hyperemic area under the curve (AUC-H), can predict EAD in liver transplant recipients. Measurements will be performed at four predefined intraoperative timepoints: after induction of anesthesia, during the anhepatic phase, during the neohepatic phase and at the end of surgery. The primary outcome is the occurrence of EAD according to Olthoff criteria.

Key facts

Study ID

NCT07658794

Run by

Ippokrateio General Hospital of Thessaloniki

People needed

50

Starts

2026-06-01

Expected to finish

2027-06-01

Last updated by the study team

2026-07-01

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult patients aged 18 years or older
• Patients scheduled to undergo orthotopic liver transplantation
• Ability to obtain intraoperative Near-Infrared Spectroscopy measurements
• Written informed consent obtained before enrollment

You may not qualify if…

• Age younger than 18 years
• Refusal or inability to provide informed consent
• Emergency liver transplantation without sufficient time for enrollment
• Inability to perform the Vascular Occlusion Test or obtain reliable NIRS measurements
• Severe peripheral vascular disease or local upper-limb conditions interfering with monitoring

Where it is running

• Ippokrateio General Hospital of Thessaloniki — Thessaloniki, Thessaloniki, Greece

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.