Outcomes Associated With Tirbanibulin for Large Field Application on the Face in the U.S (CLEAR)

Recruiting now

Conditions studied: Actinic Keratosis (AK)

In brief

The goal of this observational study is to learn about the effectiveness of tirbanibulin among adult subjects with actinic keratosis (AK) lesions in the face. The main question it aim to answer is: How does tirbanibulin improve subject's overall appearance of the skin, improve how patient's skin looks, and improve patient's skin texture, in a 57-day observation period. Participants already taking tirbanibulin as part of their regular medical care for AK will answer online survey questions at the beginning of the study and at Day 57.

Key facts

Study ID

NCT07657988

Run by

Avant Health LLC

People needed

30

Starts

2026-04-02

Expected to finish

2026-10-01

Last updated by the study team

2026-06-18

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosed with AK on the face.
• Has clinically typical, visible, and discrete 4-12 AK lesions on the face.
• Considered as a potential candidate for tirbanibulin (Klisyri®) treatment to manage their AK lesions on the face.
• Male or female, aged 18 years and above at the time of initiation of treatment with tirbanibulin.
• Willing to avoid excessive sun or UV exposure, and/or use relevant sunscreen protection and protective clothing during the study duration.
• Able to read and write in English.
• Provide consent to participate in the study.
• Willing to comply with all study procedures (including photography tasks) and be available for the duration of the study.

You may not qualify if…

• Patients with any dermatological condition of the face that could interfere with clinical evaluations.
• Hypertrophic AK lesions, open wounds, or suspected skin cancers within proximity of the treatment area.
• Anticipated need for in-patient hospitalization or in-patient surgery within the next 2 months.
• Patients unable to comply with the requirements of the study or patients who, in the opinion of the study physician should not participate in the study.
• Patients for whom medical chart is inaccessible to physicians to complete baseline data collection.

Where it is running

• Ablon Skin Institute and Research Center — Manhattan Beach, California, United States (enrolling)
• Dermatology & Laser Center of Charleston — Charleston, South Carolina, United States (enrolling)

Full record on ClinicalTrials.gov

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