Modifiable Risk Factors for Cognitive Dysfunction in Patients With Coronary Heart Disease

Recruiting now

Conditions studied: Coronary Heart Disease, Cognitive Impairment, Mild

In brief

This prospective observational study aims to investigate the association between risk factors and cognitive function in patients with coronary heart disease (CHD), and to explore the underlying mechanisms involving metabolic parameters and multimodal imaging features. A total of 2,352 participants will be enrolled from Beijing Anzhen Hospital, Capital Medical University, China. Eligible participants are adults (≥18 years) with confirmed CHD who undergo systematic neuropsychological assessment during hospitalization. Comprehensive assessments include cognitive function tests (MMSE, MoCA, BCAT, AD8), metabolic evaluations (fasting glucose, insulin, HbA1c, ceramides), coronary computed tomography angiography (CCTA), cardiac magnetic resonance (CMR), sleep respiratory monitoring, and frailty and psychological assessments.The primary outcome is cognitive impairment. The study will identify potential risk factors and provide insights into early identification and personalized intervention strategies for cognitive decline in CHD patients.This study is led by the National Clinical Research Center for Cardiovascular Diseases and invited to be carried out by several Chinese centers including Beijing Anzhen Hospital.

Key facts

Study ID

NCT07657624

Run by

Beijing Anzhen Hospital

People needed

2352

Starts

2025-06-30

Expected to finish

2031-05-01

Last updated by the study team

2026-07-15

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥ 18 years
• Diagnosis of coronary heart disease (meeting at least one of the following):
• Coronary angiography or coronary CTA showing ≥50% stenosis in ≥1 major coronary artery;
• Established diagnosis of coronary heart disease with prior medical, interventional, or surgical treatment;
• Objective evidence of myocardial ischemia or typical clinical symptoms
• Completion of standardized neuropsychological assessment during hospitalization
• Completion of metabolic marker evaluation (fasting glucose, insulin, HbA1c, etc.) and agreement to undergo relevant imaging and functional assessments
• Provision of signed written informed consent

You may not qualify if…

• Previously diagnosed dementia.
• History of stroke, cerebral hemorrhage, or other central nervous system diseases known to cause cognitive impairment.
• Severe psychiatric disorders (e.g., schizophrenia, bipolar disorder).
• Pregnancy or breastfeeding.

Where it is running

• Beijing Anzhen Hospital — Beijing, China, China (enrolling)

Full record on ClinicalTrials.gov

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