Daily Versus Alternate-Day Oral Iron Therapy for Anemia in Second-Trimester Pregnancy

Starting soon · Not applicable

Conditions studied: Iron Deficiency Anemia, Anemia in Pregnancy

In brief

This randomized controlled trial compares daily versus alternate-day oral iron supplementation in pregnant women with iron deficiency anemia during the second trimester. The study evaluates changes in hemoglobin and serum ferritin, treatment adherence, and gastrointestinal side effects to inform more patient-centered, physiologically aligned dosing strategies.

Key facts

Study ID

NCT07657455

Run by

Pakistan Air Force (PAF) Hospital Islamabad

People needed

184

Starts

2026-09-01

Expected to finish

2027-02-01

Last updated by the study team

2026-06-18

Who can join

Age: 18 and older, up to 40. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Aged 18 to 40 years
• Pregnant women in the second trimester (13 to 27 weeks gestation)
• Hemoglobin below 11 g/dL with serum ferritin below 30 ng/mL
• Singleton pregnancy

You may not qualify if…

• Known congenital or acquired hemoglobin disorders (e.g., thalassemia, hemoglobinopathies)
• Chronic diseases affecting hemoglobin levels (e.g., chronic kidney disease, inflammatory disorders)
• Bleeding disorders or a history of frequent blood loss
• Gastrointestinal conditions impairing nutrient absorption (e.g., celiac disease or other malabsorption syndromes)
• Currently receiving parenteral iron
• Requiring blood transfusion

Where it is running

• Pakistan Air Force (PAF) Hospital Islamabad — Islamabad, Pakistan

Full record on ClinicalTrials.gov

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