Intestinal Tissue-Resident Memory T Cells and HIV-1 Persistence During Antiretroviral Therapy

Starting soon · Not applicable

Conditions studied: HIV-1 Infection, HIV Reservoir, Antiretroviral Therapy

In brief

The study aims to better characterize intestinal tissue-resident memory T cells (TRM) in people living with HIV-1 receiving suppressive antiretroviral therapy (ART). TRM cells are key components of tissue immunity and may contribute to HIV-1 persistence within the intestinal mucosa, a major viral reservoir. The phenotypic, transcriptomic, and functional characteristics of intestinal CD4+ and CD8+ TRM cells, their susceptibility to HIV-1 infection, and their potential role as viral reservoirs will be investigated. Blood samples and additional colonic biopsies obtained during routine clinically indicated colonoscopy will be collected from HIV-1-infected participants and HIV-seronegative controls.

Key facts

Study ID

NCT07656077

Run by

ANRS, Emerging Infectious Diseases

People needed

30

Starts

2026-08-01

Expected to finish

2030-07-31

Last updated by the study team

2026-06-18

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

Full record on ClinicalTrials.gov

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