Targeted Temperature Management on Delayed Neurocognitive Recovery in Older Patients After Major Cancer Surgery

Starting soon · Not applicable

Conditions studied: Elderly Patients, Cancer Surgery, Hypothermia, Accidental, Targeted Temperature Management, Delayed Neurocognitive Recovery

In brief

With aging population, more older patients will receive major surgery for cancer. Older patients are at increased risk of postoperative neurocognitive complications including delayed neurocognitive recovery (dNCR), which is associated with prolonged hospital stay, raised complications, and impaired quality of life. Intraoperative hypothermia occurs in 57.1%-78.6% of patients undergoing major cancer surgery, especially in the elderly. Studies show that intraoperative hypothermia suppresses immune function, interferes with anesthetic metabolism, and delays anesthesia emergence. All these may be correlated with the occurrence of early postoperative dNCR. This study aims to verify whether intraoperative targeted temperature management (target core temperature: 36.8°C) compared with conventional temperature management (core temperature: 35.5°C) can reduce the incidence of dNCR in older patients undergoing major cancer surgery.

Key facts

Study ID

NCT07655687

Run by

Peking University First Hospital

People needed

1512

Starts

2026-06-01

Expected to finish

2028-11-01

Last updated by the study team

2026-06-23

Who can join

Age: 65 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age ≥ 65 years.
• Planned potentially curative initial cancer surgery with an expected duration of 2 hours or longer under general anesthesia.

You may not qualify if…

• Preoperative fever (tympanic temperature ≥ 38℃).
• Known or suspected preoperative infection.
• Previous schizophrenia, epilepsy, Parkinson's disease, myasthenia gravis, or preexisting delirium.
• Inability to communicate due to coma, severe dementia, or hearing or speech impairment.
• Critically ill patients, defined as NYHA functional class > III or LVEF < 30%, Child-Pugh class C, preoperative dialysis dependence, ASA physical status > IV, or expected survival < 24 hours.
• Surgery for breast cancer, intracranial tumors, or rare cancers.
• Planned to undergo therapeutic hypothermia.
• Body mass index > 30 kg/m² (to facilitate temperature management).
• Previous enrollment in this study.
• Other conditions deemed unsuitable for study participation.

Where it is running

• Peking University First Hospital — Beijing, Beijing Municipality, China
• Peking University Shenzhen Hospital — Shenzhen, Guangdong, China

Full record on ClinicalTrials.gov

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