OBSERVE: A Pilot Study Of Omission Of Brain Metastasis Stereotactic Radiosurgery Following Resection With CNS-Active Systemic Therapy

Recruiting now

Conditions studied: Brain Metastasis, Stereotactic Radiosurgery, Resection, Systemic Therapy

In brief

To remove a brain tumor, patients usually receive radiation to lower the chance that the cancer will come back in the spot where the tumor was removed.

Key facts

Study ID

NCT07655583

Run by

M.D. Anderson Cancer Center

People needed

20

Starts

2026-05-27

Expected to finish

2030-06-30

Last updated by the study team

2026-08-03

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may not qualify if…

• History of known leptomeningeal involvement (radiographic or cytological).
• Subjects that have previously received or are currently planned for whole brain radiotherapy.
• Prior unacceptable toxicity on one or more of the agents comprising the planned study systemic therapy.
• Cognitively impaired subjects with a major medical, neurologic or psychiatric condition who are judged as unable to fully comply with study therapy or assessments should not be enrolled.
• Participant unable to receive a brain MRI (implanted metal devices or foreign bodies) or MRI contrast.
• Pregnancy or plans to become pregnant during the duration of the study.

Where it is running

• MD Anderson Cancer Center — Houston, Texas, United States (enrolling)

Full record on ClinicalTrials.gov

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