Caffeine and Prophylactic Noradrenaline Requirement During Cesarean Delivery
Starting soon · Not applicable · Has a placebo group
Conditions studied: Spinal Hypotension, Vasopressor
In brief
Spinal anesthesia is the preferred regional technique in obstetric practice because it provides high maternal satisfaction and eliminates the need for airway manipulation. Despite these advantages, it is frequently complicated by spinal anesthesia-induced hypotension , defined as a reduction in systolic blood pressure of more than 20% from baseline or an absolute SBP below 100 mmHg. Spinal hypotension can have serious consequences, including maternal hypoperfusion that may lead to neurological or renal dysfunction, as well as fetal acidosis and bradycardia, which can compromise neonatal outcomes. The present study aims to evaluate the effect of preoperative caffeine administration on noradrenaline requirements during spinal anesthesia in obstetric patients. Specifically, the objectives are to compare noradrenaline requirements between the study groups and to assess the incidence of hypotension in both groups.
Key facts
- Study ID
- NCT07655245
- Run by
- Cairo University
- People needed
- 62
- Starts
- 2026-06-16
- Expected to finish
- 2026-09-19
- Last updated by the study team
- 2026-06-17
Who can join
Age: 20 and older, up to 40. Sex: female. Healthy volunteers: not accepted.
You may qualify if…
- Full-term singleton pregnant (>37 weeks)
- ASA II
- undergoing elective cesarean section.
You may not qualify if…
- Patient refusal
- SBP < 100 mmHg
- Allergy to local anesthetics or caffeine
- Coagulopathy (INR>1.4 or platelets <75.000)
- Preeclampsia
Where it is running
- Cairo University Hospitals — Cairo, Egypt
Full record on ClinicalTrials.gov
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