Risk Factor Assessment for Acute Pulmonary Hypertension Crisis
Recruiting now
Conditions studied: Pulmonary Hypertension, Pulmonary Hypertension Crisis
In brief
The goal of this observational study is to learn about pulmonary hypertension crisis (PHC) - a severe, and often fatal complication - in patients with pulmonary hypertension (PH). The main questions this study aims to answer are: What are the clinical and hemodynamic features of PHC, and what underlying pathophysiological mechanisms cause it to develop? Can these features be used to diagnostic PHC, predict who is at risk of developing it or dying from it, and develop targeted prevention and treatment of PHC? A multi-center registry platform and biobank will be established to enroll and follow up patients with PH. Clinical data, hemodynamic measurements, and biological specimen will be collected. Risk prediction and early warning tools of PHC will be developed.
Key facts
- Study ID
- NCT07653958
- Run by
- Peking Union Medical College Hospital
- People needed
- 5000
- Starts
- 2026-06-17
- Expected to finish
- 2029-12-31
- Last updated by the study team
- 2026-06-22
Who can join
Age: any. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Pulmonary hypertension confirmed by mean pulmonary arterial pressure (mPAP) over 20 mmHg measured by right heart catheter
- At least once per year of follow-up data collection record
You may not qualify if…
- Patients with missing baseline or follow-up data
- Complicated by other diseases with significant influence on survival, such as acute coronary syndrome, malignancy, etc.
- Complicated by other diseases with significant influence on hemodynamics, such as sepsis, acute left heart failure, and acute pulmonary embolism, etc.
- Receiving medications with significant influence on hemodynamics
Where it is running
- Guangdong Province People's Hospital — Guangzhou, Guangdong, China (enrolling)
- Yan'an Affiliated Hospital of Kunming Medical University — Kunming, Yunnan, China (enrolling)
- Peking Union Medical College Hospital — Beijing, China (enrolling)
- Shanghai Pulmonary Hospital — Shanghai, China (enrolling)
Full record on ClinicalTrials.gov
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