Essential Oil-Based Product System for Digestive Support

Starting soon · Not applicable · Has a placebo group

Conditions studied: Healthy

In brief

This study aims to evaluate the efficacy of specific essential oils. Efficacy will be evaluated through changes, if any, to hsCRP, gene expression, and standard hematologic and metabolic parameters, as well as subjective health changes as measured by Gastrointestinal Symptom Rating Scale (GSRS), PROMIS Global Health survey, PROMIS Fatigue Scale, Immune Fitness Item Scale (IFIS), and the Immune Status Questionnaire (ISQ) in healthy volunteers. The main questions it aims to answer are: 1. Do specific essential oils affect gene expression and hematologic and metabolic parameters as measured in blood? 2. How do essential oils affect gut microbiome? 3. How does daily use of specific essential oils affect subjective quality of life and health parameters? 4. Is ingesting and topically applying specific essential oils daily safe, as measured by laboratory tests and adverse events? Two study products will be used: oil for topical use, supplement for internal use. The two products will be used together and compared to a placebo group. The topical oil contains a blend of ginger essential oil, peppermint essential oil, caraway essential oil, coriander essential oil, and anise essential oil. The supplement contains everything the oil has, plus anise essential oil. Participants will: * Be assigned one of the two groups. * Use the oil topically once each day for 4 weeks. * Take one supplement in the morning and one in the evening every day for 4 weeks. * Attend 2 study visits in which they provide blood and urine (females only) samples. * Complete 2 stool collection/microbiome kits * Complete surveys and subjective health assessments

Key facts

Study ID: NCT07653815
Run by: dōTERRA International
People needed: 40
Starts: 2026-11-01
Expected to finish: 2026-12-01
Last updated by the study team: 2026-06-17

Who can join

Age: 18 and older, up to 45. Sex: any. Healthy volunteers: accepted.

You may qualify if…

18-45 years old
Willing to attend 2 study visits at Prime Meridian Health Clinic in Pleasant Grove, Utah
Willing and able to undergo 2 blood draws over 4 weeks
Willing to provide urine (females) and stool samples twice over 4 weeks
Willing to wash out of all internally and topically used essential oils or botanical products for at least 2 weeks prior to starting the study, and willing to maintain the washout for the duration of the study (4 weeks)
Willing and able to use study products as directed daily for about 4 weeks
Willing to avoid alcohol, recreational drugs, tobacco, and vaping for the duration of the study
Willing to track use of study products
Willing to maintain current sleep, diet, and exercise habits for the duration of the study
No major diseases under treatment by doctor (Medical Reviewer's discretion)
No pregnancy within the last 90 days or currently breastfeeding, or possibility of becoming pregnant.
No allergy to any of the ingredients in the study products
No regular consumption of the study products within the last 1 month
No alcohol, recreational drug, tobacco, or vaping use in the past 1 month
No evidence of medical condition, significant disease or disorder, medication, or surgery within the past 12 months that may, in the judgement of the medical provider, put the participant at risk or affect study results, procedures, or outcomes.
Not currently or previously participating in another clinical trial within the last 30 calendar days.

You may not qualify if…

Failure to meet all listed inclusion criteria

Where it is running

doTERRA International — Pleasant Grove, Utah, United States

Full record on ClinicalTrials.gov

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