Cascade Testing In Identifying At-risk Family Members Of Individuals With Familial Hypercholesterolemia (FH) In PCP
Starting soon · Not applicable
Conditions studied: Familial Hypercholesterolemia
In brief
The purpose of this study is to evaluate the effectiveness of two models of cascade testing in identifying at-risk family members of individuals diagnosed with familial hypercholesterolemia (FH).
Key facts
- Study ID
- NCT07653555
- Run by
- Mayo Clinic
- People needed
- 480
- Starts
- 2026-06-20
- Expected to finish
- 2029-09-20
- Last updated by the study team
- 2026-06-17
Who can join
Age: 1 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Index Patients:
- Age ≥ 18 years.
- Confirmed FH diagnosis using Dutch Lipid Clinic Network criteria *or* genetic confirmation.
- Identified through REP or Tapestry databases.
- Able and willing to provide informed consent.
- At least one eligible first- or second-degree relative.
- Access to and active use of email (computer literacy requirement).
- Relatives:
- First- or second-degree relative of an enrolled index patient.
- Age ≥ 1 year (minors require parental consent + assent).
- Willing to participate and able to complete electronic consent (guardian-assisted if minor).
- Access to and active use of email (guardian).
You may not qualify if…
- Index Patients:
- No confirmed FH diagnosis.
- Insufficient clinical follow-up (<5 years).
- No identifiable or contactable relatives.
- Prior participation in structured cascade testing.
- Severe cognitive impairment preventing informed consent.
- Relatives:
- Prior participation in structured cascade testing.
- Severe cognitive impairment preventing informed consent.
Where it is running
- Mayo Clinic in Rochester — Rochester, Minnesota, United States
Full record on ClinicalTrials.gov
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