Interplay of Central and Peripheral Vascular Effects of Insulin in Obesity

Starting soon · Early Phase 1

Conditions studied: Obesity (BMI>30), Insulin Resistance

In brief

Determine the impact of obesity with insulin resistance on the neurovascular response to brain insulin stimulation.

Key facts

Study ID

NCT07653464

Run by

University of Missouri-Columbia

People needed

64

Starts

2026-10-01

Expected to finish

2032-06-01

Last updated by the study team

2026-07-28

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 18 to 65 years of age
• Individuals with obesity and comorbid IR
• BMI 30-45 kg/m2
• Waist circumference ≥102 cm (men) or ≥88 cm (women)
• HOMA-IR ≥2.5
• Healthy normal weight adults
• BMI 18-25 kg/m2
• Waist circumference <94 cm (men) and <80 cm (women)
• HOMA-IR <2

You may not qualify if…

• Pregnancy, breastfeeding
• Unable to provide consent
• Diabetes or polycystic ovarian syndrome
• Known history of cardiovascular disease: heart failure, ischemic heart disease, peripheral artery disease, stroke
• Nerve/neurologic disease
• Uncontrolled hypertension (systolic blood pressure >180 mmHg and/or diastolic blood pressure >100 mmHg)
• Active cancer (excluding basal cell carcinoma or stage 1 squamous cell carcinoma of the skin)
• Current smoking, tobacco, nicotine use
• Use of pharmacological therapy for weight loss
• Body weight change >10% within the last 6 months
• Adherence to >150 min/week of moderate-to-vigorous physical activity/exercise
• Participation in any other research study or medical procedure involving significant ionizing radiation exposure in the past 12 months
• Claustrophobia
• Non-MRI compatible metal implants

Where it is running

• University of Missouri — Columbia, Missouri, United States

Full record on ClinicalTrials.gov

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