Contactless Ultrasound Data Acquisition in Emergency Departments to Discriminate the Origin of Dyspnea and Chest Pain

Starting soon

Conditions studied: Dyspnea, Chest Pain

In brief

PAnDA-One is a prospective, multicenter, interventional study (10 centers, France) aimed at developing and validating a diagnostic support algorithm based on the ADx-One medical device, which non-invasively acquires thoracic vibrations using airborne ultrasound. The study will enroll 2,500 patients presenting to the emergency department with acute dyspnea or non-traumatic chest pain, divided into a development cohort (N = 1,500) and an independent test cohort (N = 1,000). The deep learning algorithm will be trained to discriminate cardiovascular from non-cardiovascular origins of symptoms, and its performance will be assessed by AUROC, sensitivity, and specificity against a final diagnosis established by an expert adjudication committee. Patient management will not be modified by study participation.

Key facts

Study ID

NCT07653204

Run by

Austral Diagnostics

People needed

2500

Starts

2026-09-01

Expected to finish

2027-05-01

Last updated by the study team

2026-06-17

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Presentation to the emergency department for one or more of the following symptoms of less than 14 days' duration: acute non-traumatic dyspnea, or recent worsening of chronic dyspnea, or non-traumatic chest pain.
• Patient able to sit on a chair or on the edge of the bed
• Affiliation to national health insurance
• Able to receive study information, understand the study, and provide written informed consent

You may not qualify if…

• • Immediate need for life-saving intervention or clinical instability incompatible with study procedures.
• Shock or severe hemodynamic instability, for example systolic blood pressure <90 mmHg for at least 30 minutes or associated signs of hypoperfusion.
• Altered mental status or any condition preventing provision of valid informed consent.
• Known cognitive impairment preventing informed consent.
• Transfer to another care site before the ADx-One acquisition can be performed.
• Known pregnancy
• Minor, legally protected adult, or person deprived of liberty.
• Participation in another interventional clinical study judged incompatible with this study.

Where it is running

• La Pitié-Salpêtrière — Paris, France

Full record on ClinicalTrials.gov

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