Adjunctive Resonance-Based Chinese Five-Element Music Intervention for Depressive Disorders and Anxiety Symptoms in Male Inpatients
Enrolling by invitation · Not applicable
Conditions studied: Depressive Disorder, Anxiety, Randomised Controlled Trial
In brief
This randomized controlled trial will evaluate the effectiveness of Resonance-Based Chinese Five-Element Music Intervention (RFEMI) as an adjunct to pharmacotherapy in male inpatients with depressive disorders. Based on Traditional Chinese Medicine Five-Element tone theory and resonance-informed acoustic delivery, RFEMI will be compared with conventional music intervention plus pharmacotherapy and pharmacotherapy alone over a four-week intervention period. The study will assess changes in depressive and anxiety symptoms, TCM syndrome characteristics, neuroendocrine biomarkers, cerebral oxygenation, and autonomic nervous system regulation.
Key facts
- Study ID
- NCT07653113
- Run by
- University of Malaya
- People needed
- 100
- Starts
- 2026-06-05
- Expected to finish
- 2026-08-31
- Last updated by the study team
- 2026-06-17
Who can join
Age: 18 and older, up to 44. Sex: male. Healthy volunteers: not accepted.
You may qualify if…
- meeting both the ICD-11 diagnostic criteria for depressive episode or recurrent depressive disorder and the TCM diagnostic criteria for Yu disease
- diagnosis confirmed by two senior clinical physicians
- planned inpatient stay longer than six weeks
- no antidepressant medication in the previous six months and no music therapy in the previous year
- male sex, age 18-44 years, junior secondary education or above, clear consciousness, and ability to communicate effectively
- no other major physical disease or mental disorder
- voluntary written informed consent and complete clinical records.
You may not qualify if…
- depression due to organic mental disorder, psychoactive substance use, or non-addictive substance use
- serious organic disease or unstable vital signs
- suicidal or violent tendency, or refusal to cooperate with treatment
- hearing impairment
- inability to follow the intervention protocol
- incomplete scale data or clinical records.
Where it is running
- Datong Maternal and Child Health Hospital (formerly Datong First People's Hospital), Shanxi, China — Shanxi, Shanxi, China
Full record on ClinicalTrials.gov
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