Postprandial Effects of Fresh Mango as a Table Sugar Replacement in High-Sugar Breakfasts.

Recruiting now · Not applicable

Conditions studied: Healthy Participants

In brief

Systemic inflammation and intestinal hyperpermeability (disruption of the gut barrier which allows nutrient molecules and bacteria to enter the bloodstream) are triggered by consumption of high-sugar meals and are linked to future development of cardiovascular disease (CVD). Previous research indicates that fresh mangos have properties that have positive effects on the intestinal barrier and local gut inflammation. The investigators want to understand if replacing table sugar (sucrose) with sugar from fresh mango (which also contains fiber and plant bioactives) will lead to decreased inflammatory and permeability biomarkers after eating a high-sugar breakfast. The investigators will compare the postprandial (post meal) levels of inflammatory (IL-6) and permeability (LPS, lipid binding protein (LBP), and soluble CD14) biomarkers in blood from participants who have consumed a meal sweetened with either sucrose or fresh mango.

Key facts

Study ID

NCT07650058

Run by

Ball State University

People needed

35

Starts

2026-02-01

Expected to finish

2027-01-01

Last updated by the study team

2026-06-16

Who can join

Age: 18 and older, up to 45. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 18 - 45 years.
• Body mass index between 18.5-35.0 kg/m2
• Not pregnant or expecting to become pregnant (females only)
• Not postmenopausal (females only).
• No known chronic medical conditions (e.g., type 2 diabetes, cardiovascular disease, inflammatory diseases, etc.)
• No history of using tobacco/illicit drugs
• No history of using glucose-lowering medications/supplements.
• No history of using prescribed anti-inflammatory medications
• Does not use over-the-counter anti-inflammatory medications ≥2x/week
• Does not have a pacemaker.
• No relevant food allergies/intolerances
• Able to lay supine for at least ten minutes.

You may not qualify if…

• Not between the ages of 18-45
• Body mass index < 18.5 kg/m2 or >35.0 kg/m2
• Pregnant (females only)
• Postmenopausal status (females only).
• Been diagnosed with a chronic medical conditions (e.g., type 2 diabetes, cardiovascular disease, inflammatory diseases, etc.)
• Uses tobacco products or any illicit drugs.
• Uses glucose-lowering drugs/supplements.
• Regularly takes anti-inflammatory drugs (more than 2x week).
• Have a pacemaker.
• Allergic to mango, wheat, gluten, and/or milk.
• Unable to lay in supine position in the dark for at least ten minutes.

Where it is running

• Health Professions Building, Ball State University — Muncie, Indiana, United States (enrolling)

Full record on ClinicalTrials.gov

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