Gustabor Phase 2 - Treating Taste Changes During Cancer Therapy: A Randomized Study Evaluating an AI- Based Nutrition Intervention

Starting soon · Not applicable

Conditions studied: Multiple Myeloma (MM), GI Cancer, Taste Disorder, Melanoma (Skin Cancer), Urogenital Cancers

In brief

The study investigates taste disorders that commonly occur during or after cancer treatment, often leading to issues such as malnutrition and treatment discontinuation. Although many non-pharmacological recommendations exist, it is unclear which methods are suitable for which individuals. This randomized study aims to compare the effectiveness of individualized dietary recommendations (Gustabor group) with the current standard of care -general recommendations (Control group). Participants will undergo an objective assessment of taste disorders using taste strips and questionnaires. Based on the results, the Gustabor group will receive both general and specific dietary suggestions. These will be accomapnied by AI-generated recipe suggestions tailored to specific taste disorders (e.g., more cold foods in cases of metallic taste). The control group will receive the current standard: a flyer containing general dietary advice for oncology patients previously shown to be beneficial for managing taste alterations. The primary endpoint is the PG-SGA score within 12 weeks of inclusion.

Key facts

Study ID

NCT07649681

Run by

Wuerzburg University Hospital

People needed

198

Starts

2026-07-01

Expected to finish

2026-12-31

Last updated by the study team

2026-06-26

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥ 18
• Suffering from one of the following tumor entities: Multiple myeloma, melanoma, urogenital cancer or malignant tumor of the gastrointestinal tract
• Mainly oral nutrition
• Subjectively perceived tumor therapy-related taste disorder
• At least two clinical presentations planned within 12 weeks with a minimum interval of three weeks
• Ability to participate in nutritional intervention, including use of the online portal and implementation of recipe suggestions (e.g. resources and access to a kitchen), either independently or with third-party support (e.g. by relatives, outpatient care services).

You may not qualify if…

• Pregnancy
• Taste disorder explained by other causes (e.g. existing before therapy or COVID disease)
• Placement in an inpatient care facility

Where it is running

• Universitätsklinikum Augsburg — Augsburg, Bavaria, Germany
• Universitätsklinikum Erlangen — Erlangen, Bavaria, Germany
• LMU Klinikum Krebszentrum - CCC MünchenLMU - Comprehensive Cancer Center — München, Bavaria, Germany
• Klinikum der Technischen Universität München (TUM Klinikum) — München, Bavaria, Germany
• Universitätsklinikum Regensburg — Regensburg, Bavaria, Germany
• Universitätsklinikum Würzburg — Würzburg, Bavaria, Germany

Full record on ClinicalTrials.gov

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