Glucose Homeostasis and Shared Genetic Factors in Colorectal Cancer
Starting soon
Conditions studied: Colorectal Cancer, Diabetes Mellitus, Glucose Homeostasis
In brief
Colorectal cancer (CRC) and diabetes mellitus are two common diseases that frequently occur together and may share underlying genetic, metabolic, and immune-related mechanisms. Previous studies have shown that diabetes is associated with an increased risk of colorectal cancer and poorer clinical outcomes, while colorectal cancer itself may also influence glucose metabolism. This prospective observational study aims to investigate the relationships among glucose homeostasis, shared genetic factors, inflammatory responses, immune cell profiles, and colorectal cancer outcomes. Participants with colorectal cancer and non-colorectal cancer controls will undergo serial assessments of glucose-related biomarkers, inflammatory markers, immune cell populations, and genetic analyses over time. The study will focus on identifying shared genetic variants that may contribute to both colorectal cancer and diabetes-related traits, as well as exploring biological pathways involving inflammation, immune regulation, and metabolism. Blood samples and available colorectal tissue specimens will be analyzed to evaluate gene expression, immune cell distribution, and molecular changes associated with disease progression. The results of this study may improve understanding of the biological links between colorectal cancer and diabetes, facilitate the development of personalized risk assessment strategies, and identify potential biomarkers and therapeutic targets for patients with colorectal cancer.
Key facts
- Study ID
- NCT07648589
- Run by
- Chang Gung Memorial Hospital
- People needed
- 200
- Starts
- 2026-06-01
- Expected to finish
- 2029-05-30
- Last updated by the study team
- 2026-06-15
Who can join
Age: 20 and older, up to 85. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age 20 to 85 years
- Histologically confirmed colorectal cancer
- Newly diagnosed colorectal cancer at the time of enrollment
- No prior diagnosis of diabetes mellitus
- Ability to provide written informed consent
You may not qualify if…
- Age younger than 20 years or older than 85 years
- Pre-existing diagnosis of diabetes mellitus
- Severe obesity (body mass index ≥35 kg/m²)
- Pregnancy
- Inability or unwillingness to provide informed consent
Full record on ClinicalTrials.gov
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