Peripheral Blood CyTOF and Viral Imprinting in Postoperative Multiple Pulmonary Nodules
Starting soon
Conditions studied: Multiple Pulmonary Nodules
In brief
This multicenter prospective cohort study will enroll adults who have undergone resection of a primary pulmonary nodule and have residual multiple pulmonary nodules or require routine postoperative pulmonary nodule follow-up. During clinically indicated follow-up visits, a small amount of peripheral venous blood will be collected at the same time as routine blood draws for research CyTOF immune phenotyping and viral imprinting-related serology. The study will not assign participants to treatment, change follow-up schedules, imaging, medication, surgery, or other clinical care. Research laboratory results will not be returned to participants or entered into medical records. The study will describe longitudinal peripheral immune-cell profiles and explore associations among T/B/NK cell phenotypes, T-cell differentiation and senescence/exhaustion markers, viral imprinting markers, and postoperative residual or new pulmonary nodule evolution.
Key facts
- Study ID
- NCT07647484
- Run by
- The First Affiliated Hospital of Guangzhou Medical University
- People needed
- 200
- Starts
- 2026-07-01
- Expected to finish
- 2028-12-01
- Last updated by the study team
- 2026-06-15
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age 18 years or older, any sex. Primary pulmonary nodule has been surgically resected, with residual multiple pulmonary nodules or a need for pulmonary nodule-related routine postoperative follow-up.
- Planned routine postoperative follow-up at a participating center and able to provide a research blood sample together with routine blood draw when clinically available.
- Able to understand the study and willing to provide written informed consent before research blood sample collection.
You may not qualify if…
- Investigator judges that the participant is unsuitable for additional small-volume blood collection, such as severe anemia, obvious coagulation abnormality, recent severe bleeding, or high risk of severe vasovagal reaction.
- Acute severe infection, acute major organ dysfunction, or other condition that may substantially affect peripheral immune status and makes study participation unsuitable.
- Current strong immunosuppressive therapy that may substantially affect peripheral immune status and cannot be adequately recorded or adjusted for in analysis.
- Unable to complete informed consent or explicitly refuses use of research blood samples and related data for this study.
- Any other condition that, in the investigator's judgment, makes participation inappropriate.
Full record on ClinicalTrials.gov
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