Ultrasound Muscle Biomarkers as Predictors of Isometric Quadriceps Muscle Strength and Handgrip in Healthy Adults: an Observational Study

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Conditions studied: Healthy Adult, Muscle Strength, Skeletal Muscle Ultrasound

In brief

This observational study aims to determine whether ultrasound-derived muscle biomarkers can predict isometric quadriceps muscle strength and handgrip in healthy adults aged 18-89 years. The main questions it aims to answer are: * Which ultrasound muscle characteristics are associated with isometric quadriceps muscle strength and handgrip? * Can ultrasound-derived biomarkers be used to develop predictive models of muscle strength in healthy adults? Participants will undergo: * Ultrasound assessment of the quadriceps and forearm flexor muscles; * Measurement of isometric quadriceps muscle strength and handgrip using standardized dynamometry protocols; * Assessment of functional capacity, mobility and balance; * Completion of questionnaires related to health status, physical activity, nutrition, fatigue and health-related quality of life. The study will also assess the reliability of ultrasound measurements and explore the relationship between ultrasound variables, muscle strength, physical function and health-related factors.

Key facts

Study ID

NCT07647393

Run by

University of Alcala

People needed

300

Starts

2026-06-01

Expected to finish

2029-06-01

Last updated by the study team

2026-06-16

Who can join

Age: 18 and older, up to 89. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy adults aged 18-89 years.
• Resident in Spain for at least 5 years.
• Living independently in the community and able to complete all study assessments.
• Able to understand and follow verbal instructions in Spanish.
• Able and willing to provide written informed consent prior to study participation.

You may not qualify if…

• Neurological, musculoskeletal, or systemic disorders affecting muscle strength or mobility.
• Recent surgery or acute injury affecting the upper or lower limbs.
• Recent use of medications affecting the musculoskeletal system (e.g., systemic corticosteroids for >1 week during the previous 6 months or muscle relaxants during the previous week).
• Cognitive or psychiatric conditions limiting participation.
• Pregnancy.
• Recent postpartum period (≤3 months after delivery).
• Presence of clinically relevant pain, fatigue, physical deconditioning, or functional limitations that may interfere with study procedures or measurement validity.
• Acute illness at the time of assessment.
• Uncontrolled hypertension (≥140/90 mmHg).
• Resting peripheral oxygen saturation ≤90%.
• Moderate-to-severe pain (Numeric Rating Scale ≥4/10).
• Any medical condition considered by the investigator to contraindicate study participation.

Full record on ClinicalTrials.gov

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