Pilot Study to Evaluate Targeted Physical Activity Among Pancreatic Cancer Patients Receiving Neoadjuvant Chemotherapy

Recruiting now · Not applicable

Conditions studied: Physiological Reactivity to Cues, Physical Exercise

In brief

Patients with pancreatic cancer receiving neoadjuvant chemotherapy often experience functional decline, treatment interruptions, and clinical deterioration, and these risks may be amplified when frailty is present.

Key facts

Study ID

NCT07647250

Run by

University of Illinois at Chicago

People needed

25

Starts

2026-06-22

Expected to finish

2032-04-30

Last updated by the study team

2026-06-24

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥18 years
• Diagnosis of pancreatic cancer that is potentially resectable per the treating clinical team's assessment.
• Planned to receive or actively receiving neoadjuvant chemotherapy prior to surgery.
• Frail or pre-frail as defined by the protocol-specified frailty assessment tool (e.g., Fried Frailty Phenotype; pre-frail = 1-2 criteria; frail => 3 criteria).
• Able to provide written informed consent.
• Medically appropriate to participate in supervised, symptom-limited exercise as determined by study screening and, if indicated, the treating clinician's input.
• Able to complete study assessments and questionnaires in English or Spanish (using IRB- approved instruments/materials).

You may not qualify if…

• Adults unable to consent.
• Medical condition that, in the judgment of the investigator and/or treating clinician, makes exercise unsafe (e.g., unstable angina, uncontrolled arrhythmia, decompensated heart failure, uncontrolled severe pulmonary disease).
• Any absolute contraindication to exercise participation/testing per institutional standards.
• Severe symptoms or functional impairment that prevents safe participation despite program modification.
• Inability to comply with the intervention schedule and study procedures despite reasonable scheduling accommodations.

Where it is running

• University of Illinois Clinical Cancer Center — Chicago, Illinois, United States (enrolling)

Full record on ClinicalTrials.gov

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