Effects of Peanut Consumption on Adults With Metabolic Associated Fatty Liver Disease

Recruiting now · Not applicable

Conditions studied: MASLD, Fatty Liver

In brief

The aim of this randomized interventional trial is to understand the effects of peanut consumption on patients with metabolic associated fatty liver. The main goal is to investigate if patients who consume peanuts have improved liver marker tests as well as metabolic profile. We will also investigate how peanuts alter the gut microbes and liver fat content in patients with metabolic associated fatty liver. * Participants will be randomized into intervention (peanut consumption for 12 weeks) and control (regular diet) arm. * Stool sample and blood (for biomarkers) collection across both arms at baseline and post-intervention * Daily log to be completed for tracking peanut consumption * 2-day Dietary recall at baseline, during Week 6 and Week 12 * Poat intervention Fibro scans for participants with baseline scans available

Key facts

Study ID

NCT07646197

Run by

Henry Ford Health System

People needed

125

Starts

2026-06-09

Expected to finish

2028-06-09

Last updated by the study team

2026-08-06

Who can join

Age: 30 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 30-70 years
• do not consume peanut/peanut butter/treenut/seeds > /week
• at least one encounter-related (stage F0/F1) MASLD diagnosis (K76.0)
• Able to understand, speak, and read English
• Mentally competent to consent

You may not qualify if…

• Food allergy to peanuts or peanut-containing products
• With alcohol use disorder (AUDIT screening)
• Leukemia
• Lymphoma
• Other types of cancer
• Heart or cardiovascular diseases (such as heart attack, stroke, heart failure)
• Kidney diseases (such as chronic kidney disease, kidney transplant, renal insufficiency such as renal failure requiring dialysis)

Where it is running

• Henry Ford Health System — Detroit, Michigan, United States (enrolling)

Full record on ClinicalTrials.gov

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