Clinical Study on a New Diagnostic Strategy for Osteoporosis and Sarcopenia in Chronic Kidney Disease Patients Based on MRI-FF

Starting soon

Conditions studied: Chronic Kidney Disease, Osteoporosis

In brief

This is a single-center, observational cohort study aiming to validate the diagnostic value of MRI-FF in identifying osteoporosis and sarcopenia in patients with chronic kidney disease (CKD). A total of 868 participants, including 434 CKD patients and 434 non-CKD controls, will be enrolled at Beijing Jishuitan Hospital. All subjects will undergo MRI-FF scans of the lumbar spine and thigh to assess bone mineral density and muscle fat fraction. The primary objective is to evaluate the correlation between MRI-FF parameters and conventional diagnostic criteria for osteoporosis and sarcopenia, as well as to determine the optimal cut-off values for early detection. The study duration is from March 2026 to December 2028.

Key facts

Study ID

NCT07645794

Run by

Capital Medical University

People needed

868

Starts

2026-06-01

Expected to finish

2028-12-01

Last updated by the study team

2026-06-12

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age between 18 and 80 years old.
• Able to understand and sign the informed consent form.
• Able to complete MRI-FF scans of the lumbar spine and thigh.
• For CKD group: Confirmed diagnosis of chronic kidney disease (eGFR < 60 mL/min/1.73m² for ≥3 months).
• For control group: No history of chronic kidney disease and normal renal function.

You may not qualify if…

• Contraindications to MRI (e.g., pacemaker, metal implants, severe claustrophobia).
• History of primary bone metabolic disorders (e.g., osteoporosis, hyperparathyroidism) unrelated to CKD.
• Current use of anti-osteoporotic drugs (e.g., bisphosphonates, teriparatide).
• Severe lower limb deformity or amputation affecting thigh muscle assessment.
• Inability to cooperate with the scan due to cognitive impairment or severe illness.

Full record on ClinicalTrials.gov

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