FEEL-GOOD: A Multicenter Trial of a Mindfulness-Based Group Therapy in Young Adults With Early Psychosis

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Delusional Disorder, Brief Psychotic Disorder, Schizophreniform Disorder, Schizophrenia / Schizoaffective Disorder, Other Psychotic Disorder Not Due to A Substance or Known Physiological Condition

In brief

FEEL-GOOD is a prospective multi-site single-blinded randomized controlled trial in young inpatients with acute early psychosis. Participants are randomized 1:1 to FEEL-GOOD plus treatment as usual (TAU) or TAU alone. The intervention consists of one individual preparatory session and eight modularized group sessions delivered over four weeks involving four to eight participants at each session and including practice and homework tasks. Outcomes are assessed at baseline, 4 weeks post-intervention, and 6 months follow-up, with the primary outcome being observer-rated total psychopathology as measured with the assessed by the total score of the Positive and Negative Syndrome Scale (PANSS) post-treatment (4 weeks post baseline).

Key facts

Study ID: NCT07645443
Run by: Stephanie Mehl
People needed: 252
Starts: 2026-05-27
Expected to finish: 2028-12-31
Last updated by the study team: 2026-07-15

Who can join

Age: 16 and older, up to 35. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Age 16 to 35 years
Clinical diagnosis of early psychosis, defined as first psychotic episode within the last 5 years as assessed with the Structural Clinical Interview for DSM-5 Research Version (SCID-5-RV)
DSM-5 schizophrenia spectrum or other psychotic disorder confirmed with SCID-5-RV (DSM-5: 297.1, 298.8, 295.4, 295.9, 295.7, 298.8, 298.9) Currently receiving inpatient/day clinic treatment with a planned stay of at least 4 weeks
Interested in and willing to participate in FEEL-GOOD and/or TAU.

You may not qualify if…

Insufficient German language abilities
Acute suicidality or acute threat to others

Where it is running

University of Mannheim, Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, J5, 68169 Mannheim — Mannheim, Baden-Wurttemberg, Germany (enrolling)
University of Augsburg, Department of Psychiatry and Psychotherapy, Geschwister-Schoenert-Str. 1, 86156 Augsburg — Augsburg, Bavaria, Germany (enrolling)
Ludwig-Maximilians Universität Munich, Department of Psychiatry and Psychotherapy, Nussbaumstr. 7, 80336 Munich — München, Bavaria, Germany (enrolling)
University of Hamburg, Universitätsklinikum Hamburg-Eppendorf Hamburg, Department of Psychiatry and Psychotherapy — Hamburg, Free and Hanseatic City of Hamburg, Germany (enrolling)
Marburg University, Department of Psychiatry and Psychotherapy, Rudolf-Bultmann-Str. 8, 35039 Marburg, Germany — Marburg, Hesse, Germany (enrolling)
University of Cologne, Department of Psychiatry and Psychotherapy, Kerpener Str. 62, 50937 Cologne — Cologne, North Rhine-Westphalia, Germany (enrolling)
Charité-Universitätsmedizin Berlin (CCM), Department of Psychiatry and Psychotherapy, , Charitéplatz 1, D-10117 Berlin, Germany — Berlin, State of Berlin, Germany (enrolling)
Vivantes Klinikum am Urban, Hospital for Psychiatry, Psychotherapy und Psychosomatics, Dieffenbachstr. 1, 10967 Berlin — Berlin, State of Berlin, Germany (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.