Postoperative Non-Opioid Pain Management Utilizing Local Anesthetics Coupled With Modulated Coagulation

Starting soon · Phase 4

Conditions studied: Postoperative Pain

In brief

This study is a prospective randomized trial examining the effect of tranexamic acid (TXA) and aminocaproic acid (ε-Ahx) with local anesthetics and thrombin in all electively created surgical wound beds in hand surgery to provide long term pain relief and decrease the use of postoperative narcotics. All surgical created wounds for any hand surgery will be treated in a randomized fashion with the following four arms: 1. Bupivacaine + lidocaine 2. Bupivacaine + lidocaine + thrombin 3. Bupivacaine + lidocaine + thrombin + tranexamic acid 4. Bupivacaine + lidocaine + thrombin + aminocaproic acid All are applied topically to surgical bed prior to closure of skin.

Key facts

Study ID

NCT07644923

Run by

NYU Langone Health

People needed

40

Starts

2026-08-01

Expected to finish

2029-02-01

Last updated by the study team

2026-06-12

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18 or older
• Any patient undergoing elective hand surgery

You may not qualify if…

• Any patient with a traumatic or infected open wound (only surgically created wounds will be included)
• History of chronic pain
• History of narcotic addiction
• History of recreational drug dependency
• History of psychiatric pathology
• Allergy or hypersensitivity to local anesthetics, recombinant human thrombin or tranexamic acid
• History of coagulopathy or active thromboembolic disease
• Any patient receiving a supra/infraclavicular block for anesthesia
• Pregnancy
• Hypersensitivity to hamster proteins
• History of seizures
• Significant renal impairment (chronic kidney disease stage 3 or greater)
• History of retinal vascular disease or history of unexplained visual symptoms
• Active upper urinary tract bleeding
• History of known hypercoagulable disorder, prior thromboembolic events, or active clotting disorders
• History of severe hepatic dysfunction (active hepatitis or steatohepatitis, hepatic fibrosis considered cirrhosis)

Where it is running

• NYU Langone Health — New York, New York, United States

Full record on ClinicalTrials.gov

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