A 4-week Study Investigating Two Targeted Brightening Serum (A and B) Versus 4% Hydroquinone in Women With Mild to Severe Full-face Hyperpigmentation

Completed · Not applicable

Conditions studied: Hyperpigmentation, Melasma, Dark Spots

In brief

This a short four-week pilot study to measure the efficacy and tolerance of two brightening serums (cosmetics) versus 4% hydroquinone. The study was conducted in two sites across the USA, one in PA and in one in CA. The goal was to run the pilot study in the summer to understand the role of these two potential brightening serums in helping the appearance of skin tone evenness.

Key facts

Study ID

NCT07644871

Run by

Revision Skincare

People needed

18

Starts

2025-08-11

Expected to finish

2025-11-12

Last updated by the study team

2026-06-12

Who can join

Age: 20 and older, up to 60. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• In good general health (physical, mental, and social well-being, not merely the absence of disease/infirmity), according to subject self-report.
• Having Fitzpatrick skin type I-VI (refer to Appendix I: Fitzpatrick Skin Type)
• Age 20 to 60 years.
• Subjects with self-perceived hyperpigmented facial skin
• Having mild to severe (score of 3-9 according to a modified Griffiths scale,2 where 0 = none, 1 to 3 = mild, 4 to 6 = moderate, 7 to 9 = severe) full-face hyperpigmentation, including melasma. Hyperpigmentation and melasma must present at equal severity and size on each facial side.
• Willing to maintain visit 1/baseline condition of eyebrows and eyelashes (do not noticeably change brow/lash appearance) during the study.
• Willing to provide written informed consent and able to read, speak, write, and understand English.
• Willing to sign a photography release.
• Having not had any facial treatments in the past 6 months and are willing to withhold all facial treatments during the course of the study including facials, facial peels, photo facials, laser treatments, dermabrasion, botulinum toxin (Botox®), injectable filler treatments, intense pulsed light (IPL), acid treatments, tightening treatments, facial plastic surgery, or any other treatment administered by a physician or skin care professional designed to improve the appearance or firmness of facial skin. Waxing and threading are allowed but not facial laser hair removal.

You may not qualify if…

• Having been diagnosed with known allergies to skin care products.
• Having a known reactivity to tranexamic acid, niacinamide, sunflower seed, coconut, rosemary, barley, goji, sandalwood, licorice root, radish root, beeswax, yeast, ascorbic acid, tetrahexyldecyl ascorbate, and/or any of the ingredients in the study products.
• Breastfeeding, pregnant, or planning to become pregnant during the study according to subject self-report.
• Having a history of skin cancer within the past 5 years.
• Currently taking oral or topical prescription medications for melasma such as Triluma, compounded hydroquinone, retinoids, and tranexamic acid.
• Currently using oral or topical prescription medications for acne such as doxycycline, minocycline, clindamycin, bactrim, tetracycline, erythromycin, vibramycin, azelaic acid, benzoyl peroxide, Dapsone, or sodium sulfacetamide.

Where it is running

• Revision Skincare — Irving, Texas, United States

Full record on ClinicalTrials.gov

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