Role of Intraoperative Computed Tomography in Assessment of Spine Instability in Lumbar Degenerative Disease

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Conditions studied: Degenerative Lumbar Spine Diseases, Lumbar Spinal Instability, Degenerative Spondylolisthesis, Lumbar Spinal Stenosis

In brief

This study examines how well computed tomography (CT) imaging performed during spine surgery - known as intraoperative CT - can detect instability in the lower (lumbar) part of the spine. Spinal instability means that the bones of the spine move more than they normally should, which can contribute to pain and may affect the outcome of surgery. Before surgery, doctors usually check for this instability using X-rays taken while the patient bends forward and backward. These X-rays do not always show instability clearly. During surgery, the patient lies face down and the muscles are fully relaxed, which can change how the spine appears on imaging. The purpose of this study is to learn whether CT images taken during surgery can identify signs of lumbar spinal instability as reliably as standard imaging performed before surgery, and whether they can reveal signs of instability that were not visible beforehand. To do this, the researchers will review imaging and clinical information from adults who are undergoing surgery for degenerative (wear-related) conditions of the lower spine. This study does not change a patient's surgery or treatment. It only analyzes imaging and clinical information that are already part of standard care. The findings may help guide imaging and surgical decisions in lumbar spine surgery in the future.

Key facts

Study ID: NCT07644507
Run by: 4th Military Clinical Hospital with Polyclinic, Poland
People needed: 100
Starts: 2026-08-01
Expected to finish: 2027-12-01
Last updated by the study team: 2026-06-12

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Adults aged 18 years or older
Degenerative lumbar spine pathology requiring surgical treatment (e.g., degenerative spondylolisthesis, lumbar spinal stenosis, isthmic spondylolisthesis)
Planned or performed lumbar decompression with instrumented fusion
Available intraoperative computed tomography (CT) with comparative preoperative imaging (retrospective cohort), or intraoperative CT performed during the index surgery (prospective cohort)
No prior surgery at the spinal level under evaluation; previous surgery at other levels permitted
Stable general medical condition allowing planned clinical evaluation
Written informed consent prior to participation (prospective cohort only)

You may not qualify if…

Non-degenerative spinal pathology, including acute traumatic spinal injury, primary or metastatic spinal tumor, spinal infection (e.g., osteomyelitis, discitis), or inflammatory spinal disease (e.g., ankylosing spondylitis)
Inadequate or incomplete imaging data, including poor-quality intraoperative CT or absence of comparative preoperative imaging
Emergency or non-elective surgery
Revision surgery involving the same spinal level(s)
Inability to provide informed consent (prospective cohort only)
Neuromuscular or congenital spinal deformity significantly altering spinal biomechanics (e.g., scoliosis >20°, congenital segmentation anomalies)

Where it is running

4th Military Clinical Hospital with Polyclinic — Wroclaw, Poland

Full record on ClinicalTrials.gov

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