Effect of Pre-exercise Inhalation of Molecular Hydrogen on Metabolic Response During Graded Exercise in Healthy Women

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Healthy Adult Females

In brief

The goal of this clinical trial is to evaluate if molecular hydrogen can reduce the metabolic response during graded exercise in healthy women aged 18-30 years. The main questions it aims to answer are: * Does molecular hydrogen reduce the respiratory exchange ratio? * Does molecular hydrogen reduce oxygen uptake? Researchers will compare molecular hydrogen to a placebo (ambient air containing no molecular hydrogen) to see if molecular hydrogen reduces the metabolic response. Participants will: * Inhale molecular hydrogen for 60 minutes each day for 7 days. * Undergo an exercise testing twice after a two-week washout period.

Key facts

Study ID

NCT07644000

Run by

Palacky University

People needed

22

Starts

2026-06-22

Expected to finish

2026-12-01

Last updated by the study team

2026-06-25

Who can join

Age: 18 and older, up to 30. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Healthy female participants.
• Regular menstrual cycle with exercise testing scheduled outside the menstrual phase.
• Signed informed consent.

You may not qualify if…

• Pregnancy or breastfeeding.
• History or presence of cardiovascular disease.
• History or presence of respiratory disease.
• Regular use of medications affecting metabolism.
• Use of dietary supplements affecting metabolism within 14 days prior to intervention.
• Strenuous physical activity within 24 hours prior to exercise testing.
• Any contraindication to exercise testing or study participation determined by a physician.

Where it is running

• Palacky University, Faculty of Physical Culture — Olomouc, Czechia (enrolling)

Full record on ClinicalTrials.gov

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